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Series GSE243658 Query DataSets for GSE243658
Status Public on Jan 10, 2024
Title Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgA)
Platform organism synthetic construct
Sample organism Macaca fascicularis
Experiment type Protein profiling by protein array
Summary Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates.
We investigated airway and systemic IgG, IgA, and IgM responses in paired bronchoalveolar lavage and plasma samples prior to and two- and 5-6-months post Mtb infection using an antigen-unbiased approach with Mtb glycan and proteome-wide microarrays
 
Overall design In a case-control design, baired bronchoalveolar lavage and plasma in 57 cynomolgus macaques which, following low-dose airway Mtb infection, developed either LTBI or TB.
 
Contributor(s) Ishida E, Corrigan DT, Chen T, Liu Y, Kim RS, Song L, Rutledge TM, Magee DM, LaBaer J, Lowary TL, Lin PL, Achkar JM
Citation(s) 38096687
Submission date Sep 20, 2023
Last update date Jan 10, 2024
Contact name Jacqueline M. Achkar
E-mail(s) Jacqueline.achkar@einsteinmed.edu
Phone 7184302971
Organization name Albert Einstein College of Medicine
Street address 1300 Morris Park Ave
City Bronx
State/province NY
ZIP/Postal code 10461
Country USA
 
Platforms (1)
GPL30414 LAM Subarray 63 - Antigens 10/22/2017
Samples (270)
GSM7792590 LTBI_10011_3mo-BALF IgA
GSM7792591 LTBI_10011_3mo-Plasma IgA
GSM7792592 LTBI_10011_6mo-BALF IgA
This SubSeries is part of SuperSeries:
GSE243663 Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates
Relations
BioProject PRJNA1019351

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE243658_raw.xlsx 233.4 Kb (ftp)(http) XLSX
Raw data are available on Series record
Processed data included within Sample table

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