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| Status |
Public on Aug 01, 2005 |
| Title |
Transcriptional changes during neuronal death and replacement in the adult olfactory epithelium |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Expression profiling of mRNA abundance in the adult mouse olfactory epithelium during replacement of OSNs forced by the bilateral ablation of the olfactory bulbs. The experiment was done on 6 week old male C57Bl/6 mice. Olfactory epithelium tissue samples were collected on days 1, 5, and 7 after bulbectomy. The cellular processes activated by bulbectomy include apoptosis of mature olfactory sensory neurons, infiltration of macrophages and dendritic cells, stimulation of proliferation of basal cell progenitors, and differentation of new sensory neurons.
Keywords = olfaction
Keywords = apoptosis
Keywords = immune response
Keywords = neurogenesis
Keywords = gene silencing
Keywords = microarray
Keywords = transcription factor
Keywords = spermatogenesis
Keywords: time-course
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| Contributor(s) |
Shetty RS, Bose SC, Nickell MD, McIntyre JC, Hardin DH, Harris AM, McClintock TS |
| Citation(s) |
16027002 |
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| Submission date |
Mar 23, 2005 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Ranjit S Shetty |
| E-mail(s) |
rsshet0@hotmail.com
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| Fax |
859-323-1070
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| Organization name |
University of Kentucky
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| Department |
Physiology
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| Street address |
800 Rose Street
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| City |
Lexington |
| State/province |
KY |
| ZIP/Postal code |
40506 |
| Country |
USA |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (15)
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| GSM45678 |
Sham Day 5,# 1 |
| GSM45679 |
Sham Day 5,# 2 |
| GSM45680 |
Sham Day 5,# 3 |
| GSM45681 |
OBX Day 1,# 1 |
| GSM45682 |
OBX Day 1,# 2 |
| GSM45683 |
OBX Day 1,# 3 |
| GSM45684 |
OBX Day 5,# 1 |
| GSM45685 |
OBX Day 5,# 2 |
| GSM45686 |
OBX Day 5,# 3 |
| GSM45687 |
OBX Day 7,# 1 |
| GSM45688 |
OBX Day 7,# 2 |
| GSM45689 |
OBX Day 7,# 3 |
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| Relations |
| BioProject |
PRJNA91903 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE2437_RAW.tar |
45.0 Mb |
(http)(custom) |
TAR (of CEL, EXP, TXT) |
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