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Series GSE244988 Query DataSets for GSE244988
Status Public on Nov 05, 2023
Title Transcriptome analysis of J558 allograft mouse model treated with the CDC7-specific inhibitor TAK-931 [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To comprehensively evaluate in vivo inflammatory effects of TAK-931 in tumor microenvironment, RNA-seq was conducted in the J558 allograft mouse model. The GSEA revealed significant enrichment of inflammatory hallmarks in TAK-931-treated allografts. Metascape analyses also visualized that the network modules of the inflammatory signaling pathways were predominantly enriched.
Overall design The J558-allografted BALB/c female mice were orally administered vehicle or TAK-931 at 60 mg/kg, QD for 6 days. Vehicle and TAK-931 treated J558 allografts were analyzed using two independent samples.
Contributor(s) Kashima Y, Morita TY, Yoshiya M, Ohashi A
Citation(s) 37980406
Submission date Oct 10, 2023
Last update date Dec 08, 2023
Contact name Akihiro Ohashi
Phone +81-4-7133-1111
Organization name National Cancer Center Japan
Department Exploratory Oncology Research and Clinical Center
Lab Division of Collaborative Research and Development
Street address 6-5-1 Kashiwanoha
City Kashiwa
State/province Chiba
ZIP/Postal code 2778577
Country Japan
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7833263 J558 allograft, Vehicle-1, Day 6
GSM7833264 J558 allograft, Vehicle-2, Day 6
GSM7833265 J558 allograft, TAK-931-1, Day 6
BioProject PRJNA1026573

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE244988_RAW.tar 8.3 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA

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