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Series GSE24549 Query DataSets for GSE24549
Status Public on May 19, 2011
Title Exon level expression profiling of colorectal cancer tissue samples (test sample series).
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Colorectal cancer is a heterogeneous disease molecularly characterized by inherent genomic instabilities, chromosome instability and microsatellite instability. In the present study we propose transcriptome instability as an analogue to genomic instability on the transcriptome level. Exon microarray data from two independent series of altoghether 160 colorectal cancer tissue samples was used for global alternative splicing detection using the FIRMA algorithm (aroma.affymetrix). The sample-wise amounts of these alternative splicing scores exceeding a defined threshold (deviating exon usage amounts) were summarized to provide the basis for description of transcriptome instability. This characteristic was shown to be associated with splicing factor expression levels and patient survival in both independent sample series.
Overall design We analyzed genome-wide expression at the exon-level for two independent series of colorectal cancer tissue biopsies using the Affymetrix Human Exon 1.0 ST platform. This series of samples represents the test series.
Contributor(s) Sveen A, Ågesen TH, Rognum TO, Lothe RA, Skotheim RI
Citation(s) 21619627, 22213796
Submission date Oct 06, 2010
Last update date Feb 18, 2019
Contact name Anita Sveen
Organization name Institute for Cancer Research, Oslo University Hospital
Department Department of Molecular Oncology
Street address P.O.Box 4953, Nydalen
City Oslo
ZIP/Postal code NO-0424
Country Norway
Platforms (2)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
GPL11028 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [HuEx-1_0-st-v2,coreR3,A20071112,EP.cdf]
Samples (166)
GSM712082 colorectal cancer sample C1018II [gene-level]
GSM712083 colorectal cancer sample C1022II [gene-level]
GSM712084 colorectal cancer sample C1030II_2 [gene-level]
This SubSeries is part of SuperSeries:
GSE24551 Exon level expression profiling of colorectal cancer tissue samples
BioProject PRJNA133513

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24549_RAW.tar 3.4 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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