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Series GSE246900 Query DataSets for GSE246900
Status Public on Jun 09, 2024
Title TET-mediated DNA demethylation influences histone enhancers H3K4me1 and H3K27ac in breast cancer
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The study is designed to understand the role of TET mediated demethylation and its intricate interplay with histone enhancers and loci-specific 5-hmC levels of candidate genes in breast cancer.
Overall design TET1 and TET2 depletion have been performed using siRNA-mediated gene silencing in MCF-7 breast cancer cell lines. TET-deficient and the control cells were pulled with H3k27ac and H3K4me1 antibodies followed by ChIP bead purification, library preparation, and sequencing.
Contributor(s) Ramasamy D, Rao AM, Mani S
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Submission date Nov 02, 2023
Last update date Jun 10, 2024
Contact name Samson Mani
Phone 6381741841
Organization name Cancer Institute (WIA)
Department Molecular Oncology
Street address 38, Sardar Patel Road
City Chennai
State/province Tamilnadu
ZIP/Postal code 600036
Country India
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (9)
GSM7880519 K27_TET1
GSM7880520 K27_TET2
GSM7880521 K27_CTRL
BioProject PRJNA1035071

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Supplementary file Size Download File type/resource
GSE246900_RAW.tar 100.0 Kb (http)(custom) TAR (of NARROWPEAK)
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Raw data are available in SRA
Processed data provided as supplementary file

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