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| Status |
Public on Nov 24, 2023 |
| Title |
Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Many physiological functions regulated by osteocalcin are affected in adult offspring of mothers experiencing an unhealthy pregnancy. Furthermore, osteocalcin signaling during gestation influences cognition and adrenal steroidogenesis in adult mice. Together these observations suggest that osteocalcin functions during pregnancy may be a broader determinant of organismal homeostasis in adult mammals than previously thought. To test this hypothesis, we analyzed in unchallenged wildtype and Osteocalcin-deficient, newborn, and adult mice of various genotypes and origin, and that were maintained on different genetic backgrounds, the functions of osteocalcin in the pancreas, liver and testes and their molecular underpinnings. This analysis revealed that providing mothers are themselves Osteocalcin-deficient, Osteocalcin haploinsufficiency in embryos hampers insulin secretion, liver gluconeogenesis, glucose homeostasis, testes steroidogenesis in adult offspring; inhibits cell proliferation in developing pancreatic islets and testes; and disrupts distinct programs of gene expression in these organs and in the brain. This study indicates that provided mothers lack an allele, osteocalcin exerts dominant functions. Furthermore, through their synergistic regulation of multiple physiological functions, osteocalcin of maternal and embryonic origins contributes to the establishment and maintenance of organismal homeostasis in newborn and adult offspring.
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| Overall design |
To investigate the influence of maternal osteocalcin during gestation in the physiology of the offspring postnatally
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| Contributor(s) |
Correa Pinto D Jr, Canal Delgado I, Yang H, Clemenceau A, Corvelo A, Narzisi A, Musunuri R, Meyer Berger J, Hendricks L, Tokumura K, Luo N, Li H, Oury F, Ducy P, Yadav V, Li X, Karsenty G |
| Citation(s) |
38228788 |
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| Submission date |
Nov 19, 2023 |
| Last update date |
Jan 23, 2024 |
| Contact name |
Kazuya Tokumura |
| Organization name |
Gifu Pharmaceutical University
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| Department |
Bioactive Molecules
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| Lab |
Pharmacology
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| Street address |
1-25-4 Daigakunishi
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| City |
Gifu |
| ZIP/Postal code |
501-1196 |
| Country |
Japan |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA1042824 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE248211_rsem_gencode_count.txt.gz |
909.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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