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Series GSE248211 Query DataSets for GSE248211
Status Public on Nov 24, 2023
Title Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Many physiological functions regulated by osteocalcin are affected in adult offspring of mothers experiencing an unhealthy pregnancy. Furthermore, osteocalcin signaling during gestation influences cognition and adrenal steroidogenesis in adult mice. Together these observations suggest that osteocalcin functions during pregnancy may be a broader determinant of organismal homeostasis in adult mammals than previously thought. To test this hypothesis, we analyzed in unchallenged wildtype and Osteocalcin-deficient, newborn, and adult mice of various genotypes and origin, and that were maintained on different genetic backgrounds, the functions of osteocalcin in the pancreas, liver and testes and their molecular underpinnings. This analysis revealed that providing mothers are themselves Osteocalcin-deficient, Osteocalcin haploinsufficiency in embryos hampers insulin secretion, liver gluconeogenesis, glucose homeostasis, testes steroidogenesis in adult offspring; inhibits cell proliferation in developing pancreatic islets and testes; and disrupts distinct programs of gene expression in these organs and in the brain. This study indicates that provided mothers lack an allele, osteocalcin exerts dominant functions. Furthermore, through their synergistic regulation of multiple physiological functions, osteocalcin of maternal and embryonic origins contributes to the establishment and maintenance of organismal homeostasis in newborn and adult offspring.
Overall design To investigate the influence of maternal osteocalcin during gestation in the physiology of the offspring postnatally
Contributor(s) Correa Pinto D Jr, Canal Delgado I, Yang H, Clemenceau A, Corvelo A, Narzisi A, Musunuri R, Meyer Berger J, Hendricks L, Tokumura K, Luo N, Li H, Oury F, Ducy P, Yadav V, Li X, Karsenty G
Citation(s) 38228788
Submission date Nov 19, 2023
Last update date Jan 23, 2024
Contact name Kazuya Tokumura
Organization name Gifu Pharmaceutical University
Department Bioactive Molecules
Lab Pharmacology
Street address 1-25-4 Daigakunishi
City Gifu
ZIP/Postal code 501-1196
Country Japan
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (17)
GSM7908398 Testes WT at P1 1
GSM7908399 Testes WT at P1 2
GSM7908400 Testes KO at P1 1
BioProject PRJNA1042824

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Supplementary file Size Download File type/resource
GSE248211_rsem_gencode_count.txt.gz 909.6 Kb (ftp)(http) TXT
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Raw data are available in SRA

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