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Series GSE248670 Query DataSets for GSE248670
Status Public on Dec 02, 2023
Title GD3 Synthase Is a Master Regulator of Wild-Type p53–Mediated Apoptosis and Mutant p53–Mediated Tumorigenesis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We noted that the increased expression of GD3S enables breast cancer cells to evade cell death induced by the stabilization of p53 through Nutlin3A treatment, and we aim to explore the molecular mechanisms underlying these observed effects.
 
Overall design Comparative gene expression profiling analysis using RNA-seq data for MCF7 cell line with or without GD3S overexpression treated with DMSO or Nutlin3A, with triplicated samples for each of the four genotype-treatment combinations
 
Contributor(s) Anand V, Lokesh Battula V, Yin Z
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Nov 27, 2023
Last update date Dec 02, 2023
Contact name Zheng Yin
E-mail(s) zyin@houstonmethodist.org
Phone 7134417269
Organization name Houston Methodist Cancer Center
Department Systems Medicine and Bioengineering
Street address 6670 Bertner Avenue, R6 South
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (12)
GSM7918567 wildtype MCF7 cells treated by DMSO, replicate #1
GSM7918568 wildtype MCF7 cells treated by DMSO, replicate #2
GSM7918569 wildtype MCF7 cells treated by DMSO, replicate #3
Relations
BioProject PRJNA1045561

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE248670_Gene_Expression.xlsx 15.1 Mb (ftp)(http) XLSX
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Raw data are available in SRA

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