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Status |
Public on Dec 31, 2024 |
Title |
Examining differentially expressed genes and pathways within the striatum using a rodent model of DYT-TOR1A dystonia |
Organism |
Rattus norvegicus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
DYT-TOR1A (DYT1) is the most common monogenetic form of dystonia characterized by a reduced disease penetrance of 30-40% only. Environmental factors are suspected to play a major role in eliciting dystonia in DYT1 gene carriers. In line with this observation a sciatic nerve crush injury as a traumatic environmental stimulus was previously shown to induce dystonia-like movements (DLM) in the asymptomatic DYT-TOR1A rat model (∆ETorA). The primary objective of this study was to assess the underlying pathophysiological mechanisms associated with DYT1 dystonia using this “second hit” DYT1 rodent model. The striatum, as one of the pathophysiologic key structures of dystonia, was analysed twelve weeks after nerve injury by unbiased RNA-sequencing in order to identify differentially expressed genes (DEG) and pathways.
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Overall design |
Unbiased RNA-sequencing was conducted in the striatum of DYT-TOR1A rats and wt rats with the aim of discovering differentially expressed genes (DEGs) and pathways
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Contributor(s) |
Knorr S, Ip CW |
Citation missing |
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Submission date |
Dec 12, 2023 |
Last update date |
Dec 31, 2024 |
Contact name |
Chi Wang Ip |
Organization name |
University Hospital Würzburg
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Department |
Department of Neurology
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Street address |
Josef-Schneider-Str. 11
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City |
Würzburg |
ZIP/Postal code |
97080 |
Country |
Germany |
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Platforms (1) |
GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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Samples (28)
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Relations |
BioProject |
PRJNA1051580 |