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Series GSE249994 Query DataSets for GSE249994
Status Public on Dec 31, 2024
Title Examining differentially expressed genes and pathways within the striatum using a rodent model of DYT-TOR1A dystonia
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary DYT-TOR1A (DYT1) is the most common monogenetic form of dystonia characterized by a reduced disease penetrance of 30-40% only. Environmental factors are suspected to play a major role in eliciting dystonia in DYT1 gene carriers. In line with this observation a sciatic nerve crush injury as a traumatic environmental stimulus was previously shown to induce dystonia-like movements (DLM) in the asymptomatic DYT-TOR1A rat model (∆ETorA). The primary objective of this study was to assess the underlying pathophysiological mechanisms associated with DYT1 dystonia using this “second hit” DYT1 rodent model. The striatum, as one of the pathophysiologic key structures of dystonia, was analysed twelve weeks after nerve injury by unbiased RNA-sequencing in order to identify differentially expressed genes (DEG) and pathways.
 
Overall design Unbiased RNA-sequencing was conducted in the striatum of DYT-TOR1A rats and wt rats with the aim of discovering differentially expressed genes (DEGs) and pathways
 
Contributor(s) Knorr S, Ip CW
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Submission date Dec 12, 2023
Last update date Dec 31, 2024
Contact name Chi Wang Ip
Organization name University Hospital Würzburg
Department Department of Neurology
Street address Josef-Schneider-Str. 11
City Würzburg
ZIP/Postal code 97080
Country Germany
 
Platforms (1)
GPL20084 Illumina NextSeq 500 (Rattus norvegicus)
Samples (28)
GSM7968769 195_WTnaive
GSM7968770 196_WTnaive
GSM7968771 197_WTnaive
Relations
BioProject PRJNA1051580

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Supplementary file Size Download File type/resource
GSE249994_DESeq2_rpkms.txt.gz 4.9 Mb (ftp)(http) TXT
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Raw data are available in SRA

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