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| Status |
Public on Jan 15, 2024 |
| Title |
Gene expression profiling of human fibroblast MRC5 cells exposed to cigarette smoke condensate (CSC) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Smoking is the main risk factor for many lung diseases including chronic obstructive pulmonary disease. Cigarette smoke (CS) contains carcinogenic and reactive oxygen species that favor DNA mutations and perturb the homeostasis and environment of cells. CS induces lung cell senescence resulting in a stable proliferation arrest and a senescence-associated secretory phenotype. It was recently reported that senescent cell accumulation promotes several lung diseases.
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| Overall design |
Normal human fibroblast cells (MRC5) were cultured with or without Cigarette Smoke Condensate
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| Contributor(s) |
Flaman J, Palazzo A, Bernard D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 09, 2024 |
| Last update date |
Jan 15, 2024 |
| Contact name |
jean-michel flaman |
| E-mail(s) |
jean-michel.flaman@lyon.unicancer.fr
|
| Phone |
+33687477812
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| Organization name |
Inserm 1052
|
| Department |
CRCL
|
| Street address |
28 rue Laennec
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| City |
Lyon |
| ZIP/Postal code |
69373 |
| Country |
France |
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| Platforms (1) |
| GPL13497 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1062738 |
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