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Series GSE26000 Query DataSets for GSE26000
Status Public on Dec 10, 2010
Title Altered antisense-to-sense transcript ratios in breast cancer: Agilent
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense transcripts likely represent long ncRNAs. A subset of genes that mainly generate antisense transcripts in normal but not cancer cells is involved in essential metabolic processes. These findings suggest fundamental differences in global RNA regulation between normal and cancer cells that might play a role in tumorigenesis.
 
Overall design Global strand-specific transcriptome profilings of 4 samples in cancer from clinical breast tissue using Agilent Technologies Custom microarray.
 
Contributor(s) Polyak K, Reo M, Shipitsin M, Choudhury S, Wu ZJ, Liu XS
Citation(s) 21098291
Submission date Dec 10, 2010
Last update date Mar 23, 2012
Contact name Kornelia Polyak
E-mail(s) kornelia_polyak@dfci.harvard.edu
Phone 617-632-2106
Organization name Dana-Farber Cancer Institute
Department Medical Oncology
Lab Polyak
Street address 450 Brookline Ave
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
 
Platforms (1)
GPL11305 Agilent Technologies Custom microarray (SurePrint G3 Custom CGH, 8 Å~ 60 K)
Samples (4)
GSM638125 breast_cancer_T2
GSM638126 breast_cancer_T3
GSM638127 breast_cancer_T4
This SubSeries is part of SuperSeries:
GSE25292 Altered antisense-to-sense transcript ratios in breast cancer
Relations
BioProject PRJNA142363

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26000_RAW.tar 23.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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