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| Status |
Public on May 08, 2013 |
| Title |
Gene expression profiles of CD8+ T Lymphocytes isolated from HTLV-1 infected individuals |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by SAGE
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| Summary |
HTLV-1 is the etiologic agent of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD8+ T cells may contribute to the protection or development of HAM/TSP. In this study we used SAGE to assess gene expression profiles of CD8+ T cells isolated from HTLV-1 asymptomatic carriers (HAC) and from HAM/TSP patients, in order to identify genes involved in the HAM/TSP development. Analysis of SAGE was conducted by pooling samples according to clinical status. The comparison of gene expression profiles between controls and HAC or HAM/TSP identified around 900 genes. HAC versus HAM/TSP libraries showed 285 differentially expressed genes. We found that CXCR4 had a lower expression level in the HTLV-1 infected group than in controls. CCL5 had higher expression in HAM/TSP group, as compared to HAC. Our results provide a large-scale perspective of gene expression that may be further tested with functional assays to increase our understanding on the HTLV1-related diseases pathology.
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| Overall design |
Comparative analysis of gene expression profiles of CD8+ T Lymphocytes isolated from HTLV-1 infected individuals.
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| Citation missing |
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| Submission date |
Dec 17, 2010 |
| Last update date |
May 08, 2013 |
| Contact name |
Daniel Guariz Pinheiro |
| E-mail(s) |
dgpinheiro@usp.br
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| Phone |
+55-16-2101-9300
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| Organization name |
Faculdade de Medicina de Ribeirão Preto (Universidade de São Paulo)
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| Department |
Departamento de Genética
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| Lab |
Laboratório de Genética Molecular e Bioinformática
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| Street address |
Rua Tenente Catão Roxo, 2501
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| City |
Ribeirão Preto |
| State/province |
São Paulo |
| ZIP/Postal code |
14051-140 |
| Country |
Brazil |
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| Platforms (1) |
| GPL4 |
SAGE:10:NlaIII:Homo sapiens |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA135263 |
