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| Status |
Public on May 25, 2011 |
| Title |
Functional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles [mRNA] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparison of mRNA expression profiles in W12 Series 1 cervical ectokeratinocytes at passage number 22 versus 19 (during which time the cells gain an invasive phenotype)
As these cells demonstrate gain of chromosome 5p during this time, mRNA expression profiling data interrogated for over-expressed genes on 5p that may be important in cervical neoplastic progression.
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| |
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| Overall design |
Analyzed global mRNA expresion profiles from W12 Series 1 cells (3 replicates at passage 22 versus 3 replicates at passage 19)
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| |
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| Contributor(s) |
Murray MJ, Muralidhar B, Winder DM, Palmer RD, Barbosa-Morais N, Saini HK, Roberts I, Pett MR, Coleman N |
| Citation(s) |
21590768 |
| |
| Submission date |
Dec 20, 2010 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Matthew Jonathan Murray |
| E-mail(s) |
mjm16@cam.ac.uk
|
| Phone |
07976413769
|
| Organization name |
MRC Cancer Cell Unit
|
| Department |
MRC/Hutchison Research Centre
|
| Lab |
2.5
|
| Street address |
Box 197, Hills Road
|
| City |
Cambridge |
| ZIP/Postal code |
CB2 0XZ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (6)
|
| GSM642846 |
W12 cervical ectokeratinocytes, Series 1 passage 19 (p19) #1 |
| GSM642847 |
W12 cervical ectokeratinocytes, Series 1 passage 19 (p19) #2 |
| GSM642848 |
W12 cervical ectokeratinocytes, Series 1 passage 19 (p19) #3 |
| GSM642849 |
W12 cervical ectokeratinocytes, Series 1 passage 22 (p22) #1 |
| GSM642850 |
W12 cervical ectokeratinocytes, Series 1 passage 22 (p22) #2 |
| GSM642851 |
W12 cervical ectokeratinocytes, Series 1 passage 22 (p22) #3 |
|
| This SubSeries is part of SuperSeries: |
| GSE26177 |
Functional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles |
|
| Relations |
| BioProject |
PRJNA142389 |
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