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| Status |
Public on Apr 20, 2024 |
| Title |
Expression data from SNU-449 cells transfected with USP48 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Deubiquitinating enzymes (DUBs) are divided into seven subgroups based on sequence and structure and perform the roles of mediating the deubiquitination of substrate proteins, regulating protein function, and participating in various cellular life activities. Among them, the ubiquitin-specific protease family (USP) is the DUB subtype with the most members and structural diversity discovered so far. USP48 is a member of the USP family of ubiquitin-specific proteases and has been found to promote glioblastoma by deubiquitinating the Gli1 transcription factor and to promote the progression of non-small-cell lung cancer through inhibition of the Wnt/β-catenin signaling pathway.
We used microarrays to detail changes in gene expression regulated by USP48 overexpression in HCC cells.
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| Overall design |
Alterations in gene expression were noted in SNU-449 cells that underwent stable transfection with USP48 overexpression, in comparison to SNU-449 cells transfected with a control empty vector.
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| Contributor(s) |
Tang B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 17, 2024 |
| Last update date |
Apr 20, 2024 |
| Contact name |
Bo Tang |
| Organization name |
The First Affiliated Hospital of Guangxi Medical University
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| Street address |
No. 6 Shuangyong Road
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| City |
Nanning |
| ZIP/Postal code |
530021 |
| Country |
China |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (6)
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| GSM8213693 |
SNU-449 cells transfected with vector, rep1 |
| GSM8213694 |
SNU-449 cells transfected with vector, rep2 |
| GSM8213695 |
SNU-449 cells transfected with vector, rep3 |
| GSM8213696 |
SNU-449 cells transfected with USP48, rep1 |
| GSM8213697 |
SNU-449 cells transfected with USP48, rep2 |
| GSM8213698 |
SNU-449 cells transfected with USP48, rep3 |
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| Relations |
| BioProject |
PRJNA1101422 |
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