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Series GSE264186 Query DataSets for GSE264186
Status Public on Apr 20, 2024
Title Expression data from SNU-449 cells transfected with USP48
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Deubiquitinating enzymes (DUBs) are divided into seven subgroups based on sequence and structure and perform the roles of mediating the deubiquitination of substrate proteins, regulating protein function, and participating in various cellular life activities. Among them, the ubiquitin-specific protease family (USP) is the DUB subtype with the most members and structural diversity discovered so far. USP48 is a member of the USP family of ubiquitin-specific proteases and has been found to promote glioblastoma by deubiquitinating the Gli1 transcription factor and to promote the progression of non-small-cell lung cancer through inhibition of the Wnt/β-catenin signaling pathway.
We used microarrays to detail changes in gene expression regulated by USP48 overexpression in HCC cells.
Overall design Alterations in gene expression were noted in SNU-449 cells that underwent stable transfection with USP48 overexpression, in comparison to SNU-449 cells transfected with a control empty vector.
Contributor(s) Tang B
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Submission date Apr 17, 2024
Last update date Apr 20, 2024
Contact name Bo Tang
Organization name The First Affiliated Hospital of Guangxi Medical University
Street address No. 6 Shuangyong Road
City Nanning
ZIP/Postal code 530021
Country China
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (6)
GSM8213693 SNU-449 cells transfected with vector, rep1
GSM8213694 SNU-449 cells transfected with vector, rep2
GSM8213695 SNU-449 cells transfected with vector, rep3
BioProject PRJNA1101422

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Supplementary file Size Download File type/resource
GSE264186_RAW.tar 24.2 Mb (http)(custom) TAR (of CEL)

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