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| Status |
Public on May 16, 2024 |
| Title |
Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
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| Summary |
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/38775809/
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| Citation(s) |
38775809 |
| |
| Submission date |
May 01, 2024 |
| Last update date |
Aug 15, 2024 |
| Contact name |
Yi Sui |
| E-mail(s) |
suiyi12002@126.com
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| Organization name |
Shanghai Jiao Tong University School of Medicine
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| Street address |
South Chongqing Road
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| City |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
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| Platforms (3) |
| GPL21273 |
HiSeq X Ten (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (74)
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| GSM8246094 |
SmoWT-2, Input |
| GSM8246095 |
SMB56-1, H3K27ac, ChIP |
| GSM8246096 |
SMB56-1, Input |
| GSM8246097 |
SMB56-2, H3K27ac, ChIP |
| GSM8246098 |
SMB56-2, Input |
| GSM8246099 |
SmoWT-MB-GLI2-deltaN, HA-tag, ChIP |
| GSM8246100 |
SmoWT-MB-GLI2-deltaN, Input |
| GSM8246101 |
SHH-MB_PDX1, H3K27ac, ChIP |
| GSM8246102 |
SHH-MB_PDX1, Input |
| GSM8246103 |
SHH-MB_PDX2, H3K27ac, ChIP |
| GSM8246104 |
SHH-MB_PDX2, Input |
| GSM8246121 |
SmoWT-MB, DMSO, 8h, in vitro, rep1 |
| GSM8246122 |
SmoWT-MB, DMSO, 8h, in vitro, rep2 |
| GSM8246123 |
SmoWT-MB, JQ1, 8h, in vitro, rep1 |
| GSM8246124 |
SmoWT-MB, JQ1, 8h, in vitro, rep2 |
| GSM8246125 |
SmoWT-MB, THZ1, 8h, in vitro, rep1 |
| GSM8246126 |
SmoWT-MB, THZ1, 8h, in vitro, rep2 |
| GSM8246127 |
SmoWT-MB, DMSO, 24h, in vitro, rep1 |
| GSM8246128 |
SmoWT-MB, DMSO, 24h, in vitro, rep2 |
| GSM8246129 |
SmoWT-MB, GDC-0449, 24h, in vitro, rep1 |
| GSM8246130 |
SmoWT-MB, GDC-0449, 24h, in vitro, rep2 |
| GSM8246131 |
SmoWT-MB, DMSO, 24h, ex vivo, rep1 |
| GSM8246132 |
SmoWT-MB, DMSO, 24h, ex vivo, rep2 |
| GSM8246133 |
SmoWT-MB, GDC-0449, 24h, ex vivo, rep1 |
| GSM8246134 |
SmoWT-MB, GDC-0449, 24h, ex vivo, rep2 |
| GSM8246135 |
SmoWT-MB, DMSO, i.g., rep1 |
| GSM8246136 |
SmoWT-MB, DMSO, i.g., rep2 |
| GSM8246137 |
SmoWT-MB, GDC-0449, i.g., rep1 |
| GSM8246138 |
SmoWT-MB, GDC-0449, i.g., rep2 |
| GSM8246139 |
SmoWT-MB, DMSO, 16h, ex vivo, rep1 |
| GSM8246140 |
SmoWT-MB, DMSO, 16h, ex vivo, rep2 |
| GSM8246141 |
SmoWT-MB, AZD4573, 16h, ex vivo, rep1 |
| GSM8246142 |
SmoWT-MB, AZD4573, 16h, ex vivo, rep2 |
| GSM8246143 |
SmoWT-MB, THZ531, 16h, ex vivo, rep1 |
| GSM8246144 |
SmoWT-MB, THZ531, 16h, ex vivo, rep2 |
| GSM8246145 |
SMB56, DMSO, 8h, in vitro, rep1 |
| GSM8246146 |
SMB56, DMSO, 8h, in vitro, rep2 |
| GSM8246147 |
SMB56, JQ1, 8h, in vitro, rep1 |
| GSM8246148 |
SMB56, JQ1, 8h, in vitro, rep2 |
| GSM8246149 |
SMB56, THZ1, 8h, in vitro, rep1 |
| GSM8246150 |
SMB56, THZ1, 8h, in vitro, rep2 |
| GSM8246151 |
SMB56, GDC-0449, 8h, in vitro, rep1 |
| GSM8246152 |
SMB56, GDC-0449, 8h, in vitro, rep2 |
| GSM8246153 |
SMB56, DMSO, 24h, ex vivo, rep1 |
| GSM8246154 |
SMB56, DMSO, 24h, ex vivo, rep2 |
| GSM8246155 |
SMB56, GDC-0449, 24h, ex vivo, rep1 |
| GSM8246156 |
SMB56, GDC-0449, 24h, ex vivo, rep2 |
| GSM8246157 |
SMB56, DMSO, 20h, in vitro, rep1 |
| GSM8246158 |
SMB56, DMSO, 20h, in vitro, rep2 |
| GSM8246159 |
SMB56, AZD4573, 20h, in vitro, rep1 |
| GSM8246160 |
SMB56, AZD4573, 20h, in vitro, rep2 |
| GSM8246161 |
SMB56, SR4835, 20h, in vitro, rep1 |
| GSM8246162 |
SMB56, SR4835, 20h, in vitro, rep2 |
| GSM8246163 |
SmoWT-MB-GR, rep1 |
| GSM8246164 |
SmoWT-MB-GR, rep2 |
| GSM8246165 |
SmoWT-MB intracranial xenograft, rep1 |
| GSM8246166 |
SmoWT-MB intracranial xenograft, rep2 |
| GSM8246167 |
P60 cerebellum, rep1 |
| GSM8246168 |
P60 cerebellum, rep2 |
| GSM8246169 |
P7 cerebellum, rep1 |
| GSM8246170 |
P7 cerebellum, rep2 |
| GSM8246171 |
SHH-MB_PDX1, DMSO, 16h, rep1 |
| GSM8246172 |
SHH-MB_PDX1, DMSO, 16h, rep2 |
| GSM8246173 |
SHH-MB_PDX1, JQ1, 16h, rep1 |
| GSM8246174 |
SHH-MB_PDX1, JQ1, 16h, rep2 |
| GSM8246175 |
SHH-MB_PDX1, THZ1, 16h, rep1 |
| GSM8246176 |
SHH-MB_PDX1, THZ1, 16h, rep2 |
| GSM8246177 |
SHH-MB_PDX1, AZD4573, 16h, rep1 |
| GSM8246178 |
SHH-MB_PDX1, AZD4573, 16h, rep2 |
| GSM8246179 |
SHH-MB_PDX1, THZ531, 16h, rep1 |
| GSM8246180 |
SHH-MB_PDX1, THZ531, 16h, rep2 |
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| This SuperSeries is composed of the following SubSeries: |
| GSE266386 |
Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies [ChIP-seq] |
| GSE266389 |
Suppressing Aberrant Hedgehog Pathway and Overcoming Resistance to Smoothened Antagonists via Targeting Super-enhancer-driven Transcriptional Dependencies [RNA-seq] |
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| Relations |
| BioProject |
PRJNA1106892 |
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