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Series GSE2677 Query DataSets for GSE2677
Status Public on Nov 14, 2005
Title Prednisolone treated childhood ALL samples
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Glucocorticoids (GC) are in most chemotherapy protocols for lymphoid malignancies, particularly childhood acute lymphoblastic leukaemia (ALL) for their ability to induce apoptosis in malignant blast. The underlying mechanism, however, has so far only been investigated in model systems. This study comprises Affymetrix hgu133 plus 2.0 analyses of
Peripheral blood lymphoblasts purified at three time points (0h, 6-8h, 24h after treatment initiation) from 13 children under therapy for ALL . Treated samples were compared to untreated (0h). This series consists of this set of microarrays. For comparison, expression profiles were generated from an adult ALL patient, peripheral blood lymphocytes from GC-exposed healthy donors, GC-sensitive and -resistant ALL cell lines and mouse thymocytes treated with GC in vivo and in vitro.
Findings. An essentially complete list of GC-regulated candidate genes in clinical settings experimental and was generated, enabling immediate analysis of any gene with respect to its potential significance for GC-induced apoptosis in these systems. Gene regulations previously thought responsible for cell death in experimental systems were reconfirmed in few children only. In contrast, a small number of genes, most not implicated in GC-induced apoptosis previously, were co-ordinately regulated in the majority of children.
Keywords = ALL
Keywords = apoptosis
Keywords = glucocorticoid
Keywords = leukemia
Keywords = pediatric oncology
Keywords: other
 
 
Contributor(s) Schmidt S, Rainer J, Riml S, Ploner C, Jesacher S, Achmüller C, Presul E, Skvortsov S, Crazzolara R, Fiegl M, Raivio T, Jänne OA, Geley S, Meister B, Kofler R
Citation(s) 16293608
Submission date May 18, 2005
Last update date Mar 25, 2019
Contact name Johannes Rainer
E-mail(s) johannes.rainer@eurac.edu
Organization name Eurac Researc
Department Institute for Biomedicine
Lab Biomedical Informatics
Street address Via A. Volta 21
City Bolzano
ZIP/Postal code 39100
Country Italy
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (39)
GSM51674 B-ALL-24-24h
GSM51675 B-ALL-24-6h
GSM51676 B-ALL-24-0h
Relations
BioProject PRJNA92085

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE2677_B-ALL-13-24h_vs_B-ALL-13-0h.xls 381.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-13-8h_vs_B-ALL.13-0h.xls 460.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-17-24h_vs_B-ALL-17-0h.xls 113.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-17-8h_vs_B-ALL-17-0h.xls 39.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-24-24h_vs_B-ALL-24-0h.xls 233.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-24-6h_vs_B-ALL-24-0h.xls 232.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-31-24h_vs_B-ALL-31-0h.xls 167.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-31-6h_vs_B-ALL-31-0h.xls 72.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-32-0h-rep_vs_B-ALL-32-0h.xls 18.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-32-24h_vs_B-ALL-32-0h.xls 199.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-32-6h_vs_B-ALL-32-0h.xls 155.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-33-24h_vs_B-ALL-33-0h.xls 60.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-33-6h_vs_B-ALL-33-0h.xls 46.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-37-24h_vs_B-ALL-37-0h.xls 155.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-37-6h_vs_B-ALL-37-0h.xls 163.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-37-BM-sorted_vs_B-ALL-37-BM-unsorted.xls 55.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-38-24h_vs_B-ALL-38-0h.xls 107.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-38-6h_vs_B-ALL-38-0h.xls 76.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-40-24h_vs_B-ALL-40-0h.xls 128.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-40-6h_vs_B-ALL-40-0h.xls 35.0 Kb (ftp)(http) XLS
GSE2677_B-ALL-43-24h_vs_B-ALL-43-0h.xls 406.5 Kb (ftp)(http) XLS
GSE2677_B-ALL-43-6h_vs_B-ALL-43-0h.xls 76.0 Kb (ftp)(http) XLS
GSE2677_E-Values-Patients.xls 42.3 Mb (ftp)(http) XLS
GSE2677_M-Values-Patients.xls 28.7 Mb (ftp)(http) XLS
GSE2677_RAW.tar 293.2 Mb (http)(custom) TAR (of CEL)
GSE2677_T-ALL-2-24h_vs_T-ALL-2-0h.xls 423.5 Kb (ftp)(http) XLS
GSE2677_T-ALL-2-8h_vs_T-ALL-2-0h.xls 450.5 Kb (ftp)(http) XLS
GSE2677_T-ALL-20-24h_vs_T-ALL-20-0h.xls 171.0 Kb (ftp)(http) XLS
GSE2677_T-ALL-20-8h_vs_T-ALL-20-0h.xls 137.0 Kb (ftp)(http) XLS
GSE2677_T-ALL-25-24h_vs_T-ALL-25-0h.xls 64.0 Kb (ftp)(http) XLS
GSE2677_T-ALL-25-6h-1ug_vs_T-ALL-25-6h.xls 13.5 Kb (ftp)(http) XLS
GSE2677_T-ALL-25-6h_vs_T-ALL-25-0h.xls 37.5 Kb (ftp)(http) XLS

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