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| Status |
Public on Jul 31, 2024 |
| Title |
DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Transcriptional mitochondrial stress response to CHCHD10 G58R protein misfolding in mouse heart, gastrocnemius, and tibalis anterior muscle the presence and absence of the DELE1 mitochondrial integrated stress responses
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| Overall design |
Transcriptomics were measured in gastrocnemius, tibialis anterior, and heat muscle from P28 mice of the following genotypes: group 1 (Chchd10+/+; Dele1+), group 2 (Chchd10+/+; Dele1-/-), group 3 (Chchd10 G58R/+; Dele1+), and group 4 (Chchd10 G58R/+; Dele1-/-) by RNA-Seq. Dele1+ indicates either Dele1+/- or Dele1+/+. Chchd10 G58R/+ mouse model has the pathogenic mutation for Autosomal Dominant Inherited Mitochondrial Myopathy (p.G58R) knocked into the equivalent position of the mouse Chchd10 gene.
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| Contributor(s) |
Lin H, Huang X, Johnson K, Elkahloun A, Narendra D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 29, 2024 |
| Last update date |
Jul 31, 2024 |
| Contact name |
Derek Paul Narendra |
| Organization name |
NINDS, NIH
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| Street address |
35 CONVENT DR, Rm. 2A-211
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| City |
BETHESDA |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (64)
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| Relations |
| BioProject |
PRJNA1141402 |
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