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GEO help: Mouse over screen elements for information. |
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Status |
Public on Jan 24, 2025 |
Title |
Deficiency of the palmitoyl acyltransferase ZDHHC7 modulates gene expression in mice after a mild chronic stress paradigm |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Chronic stress (CS) is a debilitating condition that negatively affects body and brain. In mice, CS effects range from changes in behaviour down to the level of gene expression. These effects are partly mediated by sex and sex steroid hormones, which in turn are affected by the palmitoyl acyltransferase ZDHHC7. ZDHHC7 might modulate also the response to CS via palmitoylation of sex steroid hormone receptors and other proteins critical for neuronal structure and functions. Therefore, we aimed to investigate the role of ZDHHC7 in response to CS on different system levels in a mouse model of Zdhhc7-deficiency. Female and male Zdhhc7-knockout (KO) and -wildtype (WT) mice underwent a four-week-mild CS paradigm or non-stress control (C) condition. After C or CS, amongst other analyses, brain gene expression profiles (via mRNA-seq transcriptomics) were investigated. Analyses focused on effects of genotype (KO vs. WT) or condition (C vs. CS) separately in both sexes. Our results revealed significant effects particularly in females. Female KOs showed upregulated cortistatin expression after CS (C vs. CS: p<0.05). Zdhhc7-deficiency seemed to be related to a sex-specific stress response and may reveal genetic factors of CS-resilience in female mice.
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Overall design |
Female and male Zdhhc7-KO and -WT mice underwent a four-week-mild CS paradigm or non-stress C condition. After C or CS, mRNA-seq of brain tissues (hippocampus, medial prefrontal cortex) was performed to analyse effects of genotype (KO vs. WT) or condition (C vs. CS) separately in both sexes.
*************************************************************** Submitter states that missing raw files are due to file loss. ***************************************************************
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Contributor(s) |
Hohoff C, Kerkenberg N, Zhang M, Palkowska W, Wachsmuth L, Peng M, Stiehl L, Schettler C, Zang J, Huge A, Ponimaskin E, Faber C, Baune BT, Zhang W |
Citation missing |
Has this study been published? Please login to update or notify GEO. |
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Submission date |
Nov 08, 2024 |
Last update date |
Jan 24, 2025 |
Contact name |
Christa Hohoff |
E-mail(s) |
hohoffch@uni-muenster.de
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Organization name |
University of Muenster
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Department |
Department of Psychiatry
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Street address |
Albert-Schweitzer-Campus 1, A9
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City |
Münster |
ZIP/Postal code |
48149 |
Country |
Germany |
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Platforms (1) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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Samples (80)
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GSM8619943 |
Hippocampus, KO, f, CS, 2277, biol rep 1 |
GSM8619944 |
Hippocampus, KO, f, CS, 2317, biol rep 2 |
GSM8619945 |
Hippocampus, KO, f, CS, 2399, biol rep 3 |
GSM8619946 |
Hippocampus, KO, f, CS, 2284, biol rep 4 |
GSM8619947 |
Hippocampus, KO, f, CS, 2407, biol rep 5 |
GSM8619948 |
Hippocampus, KO, f, CS, 2416, biol rep 6 |
GSM8619949 |
Hippocampus, KO, f, K, 2252, biol rep 1 |
GSM8619950 |
Hippocampus, KO, f, K, 2336, biol rep 2 |
GSM8619951 |
Hippocampus, KO, f, K, 2343, biol rep 3 |
GSM8619952 |
Hippocampus, KO, f, K, 2273, biol rep 4 |
GSM8619953 |
Hippocampus, KO, f, K, 2406, biol rep 5 |
GSM8619954 |
Hippocampus, KO, f, K, 2430, biol rep 6 |
GSM8619955 |
Hippocampus, KO, m, CS, 2269, biol rep 1 |
GSM8619956 |
Hippocampus, KO, m, CS, 2256, biol rep 2 |
GSM8619957 |
Hippocampus, KO, m, CS, 2433, biol rep 3 |
GSM8619958 |
Hippocampus, KO, m, CS, 2393, biol rep 4 |
GSM8619959 |
Hippocampus, KO, m, K, 2246, biol rep 1 |
GSM8619960 |
Hippocampus, KO, m, K, 2303, biol rep 2 |
GSM8619961 |
Hippocampus, KO, m, K, 2412, biol rep 3 |
GSM8619962 |
Hippocampus, KO, m, K, 2341, biol rep 4 |
GSM8619963 |
Hippocampus, WT, f, CS, 2274, biol rep 1 |
GSM8619964 |
Hippocampus, WT, f, CS, 2409, biol rep 2 |
GSM8619965 |
Hippocampus, WT, f, CS, 2285, biol rep 3 |
GSM8619966 |
Hippocampus, WT, f, CS, 2315, biol rep 4 |
GSM8619967 |
Hippocampus, WT, f, CS, 2397, biol rep 5 |
GSM8619968 |
Hippocampus, WT, f, CS, 2417, biol rep 6 |
GSM8619969 |
Hippocampus, WT, f, K, 2278, biol rep 1 |
GSM8619970 |
Hippocampus, WT, f, K, 2253, biol rep 2 |
GSM8619971 |
Hippocampus, WT, f, K, 2408, biol rep 3 |
GSM8619972 |
Hippocampus, WT, f, K, 2337, biol rep 4 |
GSM8619973 |
Hippocampus, WT, f, K, 2342, biol rep 5 |
GSM8619974 |
Hippocampus, WT, f, K, 2429, biol rep 6 |
GSM8619975 |
Hippocampus, WT, m, CS, 2271, biol rep 1 |
GSM8619976 |
Hippocampus, WT, m, CS, 2257, biol rep 2 |
GSM8619977 |
Hippocampus, WT, m, CS, 2434, biol rep 3 |
GSM8619978 |
Hippocampus, WT, m, CS, 2395, biol rep 4 |
GSM8619979 |
Hippocampus, WT, m, K, 2244, biol rep 1 |
GSM8619980 |
Hippocampus, WT, m, K, 2302, biol rep 2 |
GSM8619981 |
Hippocampus, WT, m, K, 2339, biol rep 3 |
GSM8619982 |
Hippocampus, WT, m, K, 2411, biol rep 4 |
GSM8619983 |
mPFC, KO, f, CS, 2277, biol rep 1 |
GSM8619984 |
mPFC, KO, f, CS, 2284, biol rep 2 |
GSM8619985 |
mPFC, KO, f, CS, 2317, biol rep 3 |
GSM8619986 |
mPFC, KO, f, CS, 2399, biol rep 4 |
GSM8619987 |
mPFC, KO, f, CS, 2407, biol rep 5 |
GSM8619988 |
mPFC, KO, f, CS, 2416, biol rep 6 |
GSM8619989 |
mPFC, KO, f, K, 2273, biol rep 1 |
GSM8619990 |
mPFC, KO, f, K, 2252, biol rep 2 |
GSM8619991 |
mPFC, KO, f, K, 2336, biol rep 3 |
GSM8619992 |
mPFC, KO, f, K, 2343, biol rep 4 |
GSM8619993 |
mPFC, KO, f, K, 2406, biol rep 5 |
GSM8619994 |
mPFC, KO, f, K, 2430, biol rep 6 |
GSM8619995 |
mPFC, KO, m, CS, 2269, biol rep 1 |
GSM8619996 |
mPFC, KO, m, CS, 2256, biol rep 2 |
GSM8619997 |
mPFC, KO, m, CS, 2393, biol rep 3 |
GSM8619998 |
mPFC, KO, m, CS, 2433, biol rep 4 |
GSM8619999 |
mPFC, KO, m, K, 2246, biol rep 1 |
GSM8620000 |
mPFC, KO, m, K, 2303, biol rep 2 |
GSM8620001 |
mPFC, KO, m, K, 2412, biol rep 3 |
GSM8620002 |
mPFC, KO, m, K, 2341, biol rep 4 |
GSM8620003 |
mPFC, WT, f, CS, 2274, biol rep 1 |
GSM8620004 |
mPFC, WT, f, CS, 2285, biol rep 2 |
GSM8620005 |
mPFC, WT, f, CS, 2315, biol rep 3 |
GSM8620006 |
mPFC, WT, f, CS, 2397, biol rep 4 |
GSM8620007 |
mPFC, WT, f, CS, 2409, biol rep 5 |
GSM8620008 |
mPFC, WT, f, CS, 2417, biol rep 6 |
GSM8620009 |
mPFC, WT, f, K, 2278, biol rep 1 |
GSM8620010 |
mPFC, WT, f, K, 2253, biol rep 2 |
GSM8620011 |
mPFC, WT, f, K, 2337, biol rep 3 |
GSM8620012 |
mPFC, WT, f, K, 2342, biol rep 4 |
GSM8620013 |
mPFC, WT, f, K, 2408, biol rep 5 |
GSM8620014 |
mPFC, WT, f, K, 2429, biol rep 6 |
GSM8620015 |
mPFC, WT, m, CS, 2271, biol rep 1 |
GSM8620016 |
mPFC, WT, m, CS, 2257, biol rep 2 |
GSM8620017 |
mPFC, WT, m, CS, 2395, biol rep 3 |
GSM8620018 |
mPFC, WT, m, CS, 2434, biol rep 4 |
GSM8620019 |
mPFC, WT, m, K, 2244, biol rep 1 |
GSM8620020 |
mPFC, WT, m, K, 2302, biol rep 2 |
GSM8620021 |
mPFC, WT, m, K, 2411, biol rep 3 |
GSM8620022 |
mPFC, WT, m, K, 2339, biol rep 4 |
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Relations |
BioProject |
PRJNA1183804 |
Supplementary file |
Size |
Download |
File type/resource |
GSE281404_RAW.tar |
14.7 Mb |
(http)(custom) |
TAR (of TXT) |
GSE281404_mRNAseq_norm_read_counts.xlsx |
33.4 Mb |
(ftp)(http) |
XLSX |
Raw data not provided for this record |
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