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Series GSE29314 Query DataSets for GSE29314
Status Public on May 20, 2011
Title Identification of serum microRNAs associated with prostate cancer in a mouse model of disease
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary There is an urgent need for new biomarkers to enhance the clinical management of prostate cancer. Circulating microRNAs (miRNAs) are emerging as useful non-invasive markers of disease. The objective of this study was to test the utility of a mouse model of prostate cancer as a tool to discover serum miRNAs that could be applied in a clinical setting. Global miRNA profiling using microarrays identified 46 miRNAs at differential levels in the serum of TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice compared to their wild-type littermates.
 
Overall design Total RNA extracted from the serum of 9 mice with advanced disease was pooled into 3 groups (TRAMP serum RNA 1, 2 and 3). Serum RNA from age-matched wild-type littermates, pooled as above, served as the control set.
 
Contributor(s) Selth LA, Butler LM, Tilley WD
Citation(s) 22052531
Submission date May 16, 2011
Last update date May 02, 2017
Contact name Luke Selth
E-mail(s) luke.selth@flinders.edu.au
Organization name Flinders University
Department College of Medicine and Public Health
Street address Flinders Drive
City Bedford Park
State/province SA
ZIP/Postal code 5042
Country Australia
 
Platforms (1)
GPL8786 [miRNA-1] Affymetrix Multispecies miRNA-1 Array
Samples (6)
GSM724444 TRAMP_serum_advancedDiseased_rep1
GSM724445 TRAMP_serum_advancedDiseased_rep2
GSM724446 TRAMP_serum_advancedDiseased_rep3
Relations
BioProject PRJNA138651

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29314_RAW.tar 770.0 Kb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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