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Series GSE29354 Query DataSets for GSE29354
Status Public on May 19, 2011
Title Mesothelioma tumor gene expression profiles
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated genomic analysis of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic inactivating mutations in BAP1 in 23% of MPM. The BAP1 nuclear deubiquitinase is known to target histones (together with ASXL1 as a Polycomb repressor subunit) and the HCF1 transcriptional co-factor, and we show that BAP1 knockdown in MPM cell lines affects E2F and Polycomb target genes. These findings implicate transcriptional deregulation in the pathogenesis of MPM.
Overall design Total RNA from 53 pleural mesothelioma tumors was extracted and hybridized to Affymetrix gene expression arrays to compile a set of gene expression profiling data for this disease.
Contributor(s) Ladanyi M, Bott M
Citation(s) 21642991
Submission date May 17, 2011
Last update date Aug 10, 2018
Contact name Yupu Liang
Organization name The Rockefeller University
Street address 1230 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (53)
GSM725566 100
GSM725567 101
GSM725568 102
This SubSeries is part of SuperSeries:
GSE29211 The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
BioProject PRJNA142999

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE29354_RAW.tar 181.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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