GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE30082 Query DataSets for GSE30082
Status Public on Aug 01, 2013
Title IkBa associates with histone H2A in human keratinocytes
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Here, we demonstrate that IkBa displays a predominant and unique nuclear localization in normal basal keratinocytes. This nuclear IkBa binds the chromatin through direct interaction of the ankyrin repeats with histone H2A and associates with the promoter and regulatory regions of several developmental-related genes including HOXA10, HOXB2 and HOXB9. Most importantly, IkBa dictates the competence of these HOX genes to be activated upon TNFa stimulation.
Overall design Examination of IkBalpha location in keratinocyte cells
Contributor(s) Espinosa L, Islam A, Mulero MC, Bigas A, Lopez-Bigas N
Citation(s) 23850221
Submission date Jun 19, 2011
Last update date May 15, 2019
Contact name Lluis Espinosa
Phone +34-933160589
Organization name Hospital del Mar
Department Institut Municipal d'Investigacions Mèdiques, (IMIM)
Lab Stem Cell and Cancer
Street address Dr. Aiguader 88
City Barcelona
State/province Barcelona
ZIP/Postal code 08003
Country Spain
Platforms (1)
GPL9052 Illumina Genome Analyzer (Homo sapiens)
Samples (1)
GSM744581 IkBa_ChIPSeq
SRA SRP007333
BioProject PRJNA144069

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE30082_RAW.tar 194.5 Mb (http)(custom) TAR (of BED, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap