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Series GSE3255 Query DataSets for GSE3255
Status Public on Dec 01, 2005
Title Gene Expression Profiles with Common Translocations in Acute Myeloid Leukemia (AML) using SAGE
Organism Homo sapiens
Experiment type Expression profiling by SAGE
Summary SAGE was used to profile gene expression in leukemic myeloid progenitor cells of AML patients with t(8;21), t(15;17), t(9;11) and inv(16).
Keywords: SAGE analysis of gene expression in leukemic myeloid progenitor cells isolated from bone marrow
Overall design Bone marrow cells from 4 patients with de novo t(9;11), 3 with treatment-related t(9;11), and 5 each with inv(16), t(15;17), t(8;21) were used for the study. Each sample contained at least 75% affected cells with no other chromosome abnormalities at cytogenetic level. Mononuclear cells were purified from bone marrow cells for each sample, and CD15+ myeloid progenitor cells were isolated from these mononuclear cells. Poly A+ RNA were isolated from CD15+ myeloid progenitor cells of each sample for SAGE tag collection.
Contributor(s) Lee S, Chen J, Zhou G, Shi RZ, Bouffard G, Kocherginsky M, Ge X, Sun M, Jayathilaka N, Kim YC, Emmanuel N, Bohlander S, Minden M, Liu P, Kline J, Ozer O, Larson R, LeBeau M, Green E, Trent J, Karrison T, Wang (Correspondence) SM, Rowley (Correspondence) JD
Citation(s) 16418266
Submission date Sep 06, 2005
Last update date Sep 20, 2012
Contact name San Ming Wang
Phone 224-364-7491
Fax 224-364-5003
Organization name ENH Research Institute, Northwestern University
Department Center for Functional Genomics
Street address 1001 University Place
City Evanston
State/province IL
ZIP/Postal code 60062
Country USA
Platforms (1)
GPL4 SAGE:10:NlaIII:Homo sapiens
Samples (22)
GSM73364 AML_INV(16)_LIB1
GSM73365 AML_INV(16)_LIB2
GSM73366 AML_INV(16)_LIB3
BioProject PRJNA92907

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