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Series GSE32720 Query DataSets for GSE32720
Status Public on Nov 01, 2011
Title DMD vs. AGING
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Comparative effects of Duchenne Muscular Dystrophy (DMD) and Aging in skeletal muscle
Expression profiling established by microarray technology provides a powerful tool by which complex pathways can be assembled. The pathophysiology of Duchenne Muscular Dystrophy (DMD) is a complex process involving many pathways downstream of the primary genetic insult (lack of dystrophin). Similarly, the mechanisms implicated in muscle aging are only partially understood. The objective of the present study was to compare the muscle transcriptional response downstream of lack of dystrophin with the molecular events associated with aging using a muscle-dedicated microarray. Defining a common transcriptional profile in a range of wasting diseases should increase our understanding of the critical adaptations associated with muscle atrophy independent of the cause of the muscle wasting.
Overall design RNA samples from 4 DMD and 4 AGE skeletal muscle tissues were analyzed by hybridization against control samples. This hybridization was done on microarrays containing quadruplicate 50-mer oligonucleotides corresponding to 3,588 muscle relevant genes. Two hybridizations were per-formed for each subject. Thus, eight values per gene were obtained for each subject. These stringent conditions conferred powerful significance to our results.
Contributor(s) Baron D, Bihouée A, Teusan R
Citation(s) 22096509
Submission date Oct 10, 2011
Last update date Mar 23, 2012
Contact name Daniel BARON
Organization name Institut national de la santé et de la recherche médicale-INSERM
Department UMR1064 - Centre de Recherche en Transplantation & Immunologie
Lab Tolerance et regulation lymphocytaire
Street address 30 Bd Jean Monnet
City Nantes
State/province Loire-Atlantique (44)
ZIP/Postal code 44093
Country France
Platforms (1)
GPL14713 Human MyoChip 17K oligonucleotide array
Samples (16)
GSM813015 Aging muscular sample 1 Replicate 1
GSM813016 Aging muscular sample 1 Replicate 2
GSM813017 Aging muscular sample 2 Replicate 1
BioProject PRJNA146791

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Supplementary file Size Download File type/resource
GSE32720_RAW.tar 21.7 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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