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Status |
Public on Dec 31, 2013 |
Title |
Analysis of Fetal liver cells from hnRNP L KO mice |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
The regulation of post-transcriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development and immunity. To investigate the role of hnRNP L in this process, we have generated conditional hnRNP L knockout mice carrying floxed alleles in order to generate a specific defect in hnRNP L activity. We have previously characterized defects present in the thymocytes of hnRNP L -/- mice and the current study extends the analysis to examine the effects in fetal liver cells. Overall these cells exhibit a very different phenotype from thymocytes characterized by significant cell death and a potential block in proliferation. Further functional studies were performed to better characterize these effects.
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Overall design |
RNA-seq from fetal liver cells of WT mice compared to KO (hnRNP L) mice
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Contributor(s) |
Möröy T, Gaudreau M, Wilhelm BT |
Citation missing |
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Submission date |
Nov 18, 2011 |
Last update date |
May 15, 2019 |
Contact name |
Brian Wilhelm |
E-mail(s) |
brian.wilhelm@umontreal.ca
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Organization name |
University of Montreal
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Street address |
2950 Chemin Polytechnique
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City |
Montreal |
ZIP/Postal code |
H1J 3R4 |
Country |
Canada |
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Platforms (1) |
GPL9318 |
AB SOLiD System 3.0 (Mus musculus) |
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Samples (4)
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Relations |
SRA |
SRP009415 |
BioProject |
PRJNA148143 |