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Series GSE33815 Query DataSets for GSE33815
Status Public on Dec 31, 2013
Title Analysis of Fetal liver cells from hnRNP L KO mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The regulation of post-transcriptional modifications of pre-mRNA by alternative splicing is important for cellular function, development and immunity. To investigate the role of hnRNP L in this process, we have generated conditional hnRNP L knockout mice carrying floxed alleles in order to generate a specific defect in hnRNP L activity. We have previously characterized defects present in the thymocytes of hnRNP L -/- mice and the current study extends the analysis to examine the effects in fetal liver cells. Overall these cells exhibit a very different phenotype from thymocytes characterized by significant cell death and a potential block in proliferation. Further functional studies were performed to better characterize these effects.
 
Overall design RNA-seq from fetal liver cells of WT mice compared to KO (hnRNP L) mice
 
Contributor(s) Möröy T, Gaudreau M, Wilhelm BT
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Submission date Nov 18, 2011
Last update date May 15, 2019
Contact name Brian Wilhelm
E-mail(s) brian.wilhelm@umontreal.ca
Organization name University of Montreal
Street address 2950 Chemin Polytechnique
City Montreal
ZIP/Postal code H1J 3R4
Country Canada
 
Platforms (1)
GPL9318 AB SOLiD System 3.0 (Mus musculus)
Samples (4)
GSM836266 Fetal liver sample for RNA-seq 1
GSM836267 Fetal liver sample for RNA-seq 2
GSM836268 Fetal liver sample for RNA-seq 3
Relations
SRA SRP009415
BioProject PRJNA148143

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE33815_RAW.tar 36.9 Gb (http)(custom) TAR (of BAM, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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