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Series GSE3474 Query DataSets for GSE3474
Status Public on Nov 17, 2005
Title HapMap Yoruban individuals vs CEPH reference
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary It is becoming clear that copy number polymorphism in the human genome is a significant form of genetic variation. We have developed a new method that uses SNP genotype data from parent-offspring trios and applied it to HapMap to conduct high-resolution detection of deletion polymorphism. Of the delections uncovered, approximately 100 have been experimentally validated using comparative genome hybridization on these tiling-resolution oligonucleotide microarrays. We identified a total of 586 distinct regions that harbor deletion polymorphisms in one or more of the parent-offspring trios. This new method will permit future identification of deletion polymorphisms from high density SNP data derived from parent-offspring trios or other family relationships.
Keywords: comparative genomic hybridisation
Overall design Eight array CGH assays/hybridisations of 131 suspected genomic regions with copy number polymorphisms.
Contributor(s) Conrad D, Andrews D, Carter NP, Hurles ME, Pritchard J
Citation(s) 16327808
Submission date Oct 19, 2005
Last update date Jan 15, 2013
Contact name Dan Andrews
Organization name Sanger Institute
Street address Wellcome Trust Genome Campus
City Hinxton
ZIP/Postal code CB10 1SA
Country United Kingdom
Platforms (1)
GPL2988 Sanger (Hurles) - Homo sapiens - 385K feature custom tiling path array - v1.0
Samples (8)
GSM78608 NA18500 (Cy3) versus NA10851 (Cy5)
GSM78609 NA18503 (Cy3) versus NA10851 (Cy5)
GSM78610 NA18506 (Cy3) versus NA10851 (Cy5)
BioProject PRJNA93281

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