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Series GSE35151 Query DataSets for GSE35151
Status Public on Jun 22, 2012
Title Genome-wide occupancy profile of Tbx3, Gata4, Nkx2-5 and p300 in adult mouse whole heart
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous gene expression by key transcription factors and transcriptional enhancers. Here, we assessed the genome-wide occupation of conduction system–regulating transcription factors TBX3, NKX2-5, and GATA4 and of enhancer-associated coactivator p300 in the mouse heart, uncovering cardiac enhancers throughout the genome.
Overall design Examination of 3 cardiac transcription factors and p300 in adult mouse heart
Contributor(s) van den Boogaard M, Barnett P, Christoffels VM
Citation(s) 22706305
Submission date Jan 17, 2012
Last update date May 15, 2019
Contact name Vincent M. Christoffels
Phone 0205667821
Organization name Amsterdam UMC
Department Medical Biology
Lab Vincent Christoffels
Street address Meibergdreef 15 K2-159
City Amsterdam
State/province N/A (NA)
ZIP/Postal code 1105 AZ
Country Netherlands
Platforms (2)
GPL9318 AB SOLiD System 3.0 (Mus musculus)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (5)
GSM862695 Heart_Tbx3_ChIP-seq
GSM862696 Heart_control_ChIP-seq
GSM862697 Heart_Gata4_ChIP-seq
SRA SRP010365
BioProject PRJNA150771

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Supplementary file Size Download File type/resource
GSE35151_RAW.tar 345.3 Mb (http)(custom) TAR (of BIGWIG, TXT, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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