|
| Status |
Public on Sep 27, 2012 |
| Title |
Genome wide array analysis of endosseous implant adherent cellular phenotypes |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Objective: to identify the early molecular processes involved in osseointegration associated with a micro roughened and nanosurface featured implants.
|
| |
|
| Overall design |
Thirty-two titanium implants with surface topographies exhibiting nanoscale features (AT-I) and microrough surface without nanoscale features (AT-II) were placed in the tibiae of 8 rats and subsequently harvested at 2 and 4 days after placement. Total RNA was isolated from cells adherent to retrieved implants. A whole genome microarray using the Affymetrix Rat gene 1.1 ST Array was used to describe the gene expression profiles that were differentially regulated by the implant surfaces.
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| |
|
| Contributor(s) |
Cooper LF, Thalji GN |
| Citation(s) |
22884725 |
| |
| Submission date |
Feb 21, 2012 |
| Last update date |
Mar 14, 2017 |
| Contact name |
Lyndon Cooper |
| Organization name |
UNC School of Dentistry
|
| Department |
Prosthodontics
|
| Lab |
Bone Biology and Implant Therapy Laboratory
|
| Street address |
330 Brauer Hall, CB#7450
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11534 |
[RaGene-1_1-st] Affymetrix Rat Gene 1.1 ST Array [transcript (gene) version] |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA151629 |
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