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Series GSE37264 Query DataSets for GSE37264
Status Public on Jun 30, 2014
Title Genome-wide profiling of altered gene expression in the neocortex of Alzheimer's disease (exon level)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We investigated genome-wide gene alterations in the temporal cortex of a well-characterized cohort of Alzheimer’s disease (AD) patients using Affymetrix exon arrays.
Overall design The AD patients and controls are subjects originally recruited into OPTIMA (Oxford Project to Investigate Memory and Ageing). Subjects underwent annual clinical and neuropsychological assessments, including the Cambridge Cognitive Examination (CAMCOG). Among subjects who died with autopsy consent given by next of kin, 1 cm3 blocks of grey matter from BA22 were dissected from fresh frozen brains of AD subjects. Tissues from elderly controls, followed longitudinally in life and with CAMCOG scores >80 at the last assessment before death, were collected. Affymetrix exon array was carried out in 8 control and 8 AD samples. The samples processed in each hybridization run were matched for AD vs. control, sex and postmortem interval (PMI) as far as possible.

This submission includes the exon-level analysis.
Contributor(s) Tan MG, Lai MK
Citation Mitchell K.P. Lai, Margaret M. Esiri, Michelle G.K. Tan. Genome-wide profiling of alternative splicing in Alzheimer's disease. Genomics Data 2 (2014) 290-292. DOI:
Submission date Apr 13, 2012
Last update date Sep 30, 2014
Contact name Michelle GK Tan
Organization name Singapore General Hospital
Department Clinical Translational Research
Street address 20 College Road
City Singapore
ZIP/Postal code 169856
Country Singapore
Platforms (1)
GPL5188 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [probe set (exon) version]
Samples (16)
GSM915110 op1044_CNT (exon level)
GSM915111 op1151_CNT (exon level)
GSM915112 op388_AD (exon level)
BioProject PRJNA159155

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE37264_RAW.tar 305.2 Mb (http)(custom) TAR (of CEL)
GSE37264_alternative_splicing_analysis.xlsx 21.9 Kb (ftp)(http) XLSX
Processed data included within Sample table

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