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| Status |
Public on Nov 19, 2014 |
| Title |
Differential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Betapolyomavirus hominis; Betapolyomavirus macacae |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Analysis of microRNA expression in vastus lateralis muscle biopsies from 11 genetically identical twin pairs discordant for type 2 diabetes. This eliminates the influence of genotype and leads to the identification of microRNAs that are exclusively influenced by environmental (non-genetic) factors.
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| Overall design |
Total RNA containing microRNAs were obtained from muscle biopsies (vastus lateralis) from genetically identical twin pairs (n=11 pairs). All twin pairs were discordant in respect to their glucose tolerance; thus, one twin has diabetes whereas the co-twin has either normal or impaired glucose tolerance.
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| Contributor(s) |
Bork-Jensen J, Scheele C, Christophersen D, Nilsson E, Friedrichsen M, Fernandez-Twinn D, Grunnet L, Litman T, Holmstrøm K, Vind B, Højlund K, Beck-Nielsen H, Wojtaszewski J, Ozanne S, Pedersen B, Poulsen P, Vaag A |
| Citation(s) |
25403480 |
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| Submission date |
Jun 20, 2012 |
| Last update date |
Nov 19, 2014 |
| Contact name |
jette bork-jensen |
| Organization name |
Rigshospitalet
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| Department |
the department of endocrionlogy (diabetes and metabolism)
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| Street address |
Tagensvej 20
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| City |
Copenhagen |
| ZIP/Postal code |
2200 |
| Country |
Denmark |
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| Platforms (1) |
| GPL7724 |
miRCURY LNA microRNA Array, v. 9.2, all organisms |
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| Samples (22)
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| GSM950571 |
Twin without type 2 diabetes, pair 2 |
| GSM950572 |
Twin with type 2 diabetes, pair 3 |
| GSM950573 |
Twin without type 2 diabetes, pair 3 |
| GSM950574 |
Twin with type 2 diabetes, pair 4 |
| GSM950575 |
Twin without type 2 diabetes, pair 4 |
| GSM950576 |
Twin with type 2 diabetes, pair 6 |
| GSM950577 |
Twin without type 2 diabetes, pair 6 |
| GSM950578 |
Twin with type 2 diabetes, pair 7 |
| GSM950579 |
Twin without type 2 diabetes, pair 7 |
| GSM950580 |
Twin with type 2 diabetes, pair 8 |
| GSM950581 |
Twin without type 2 diabetes, pair 8 |
| GSM950582 |
Twin without type 2 diabetes, pair 9 |
| GSM950583 |
Twin with type 2 diabetes, pair 9 |
| GSM950584 |
Twin without type 2 diabetes, pair 10 |
| GSM950585 |
Twin with type 2 diabetes, pair 10 |
| GSM950586 |
Twin with type 2 diabetes, pair 11 |
| GSM950587 |
Twin without type 2 diabetes, pair 11 |
| GSM950588 |
Twin without type 2 diabetes, pair 12 |
| GSM950589 |
Twin with type 2 diabetes, pair 12 |
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| Relations |
| BioProject |
PRJNA169025 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE38835_RAW.tar |
19.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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