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Series GSE39034 Query DataSets for GSE39034
Status Public on Nov 29, 2012
Title Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
Organism Mus musculus
Experiment type Methylation profiling by genome tiling array
Expression profiling by array
Summary Progression to malignancy requires cells to overcome senescence and switch to an immortal phenotype. Thus, exploring the genetic and epigenetic changes that occur during senescence/immortalization may help elucidate crucial events that lead to cell transformation. In the present study, we have globally profiled DNA methylation in relation to gene expression in primary, senescent and immortalized mouse embryonic fibroblasts.
Overall design Primary, senescent and immortalized mouse fibroblasts obtained from three independent embryos. Compare immortalized versus primary and senescent versus primary cells.
Contributor(s) Tommasi S, Zheng A, Weninger A, Bates SE, Li AX, Wu X, Hollstein M, Besaratinia A
Citation(s) 23143272
Submission date Jun 29, 2012
Last update date Feb 11, 2019
Contact name Xiwei Wu
Organization name City of Hope National Medical Center
Department Computational and Quantitative Medicine
Street address 1500 E. Duarte Rd.
City Duarte
State/province CA
ZIP/Postal code 91010
Country USA
Platforms (2)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
GPL15761 NimbleGen mouse DNA Methylation 3x720K CpG Island Plus RefSeq Promoter Arrays
Samples (17)
GSM954262 Mouse embryonic fibroblasts. Set 1, primary, passage # <6 (methylation)
GSM954263 Mouse embryonic fibroblasts. Set 1, immortalized, passage # >10 (methylation)
GSM954264 Mouse embryonic fibroblasts. Set 2, primary, passage # <6 (methylation)
BioProject PRJNA169641

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE39034_RAW.tar 406.7 Mb (http)(custom) TAR (of CEL, CHP, GFF, PAIR)
Processed data included within Sample table
Processed data provided as supplementary file

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