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Series GSE3980 Query DataSets for GSE3980
Status Public on Jan 06, 2006
Title Lineage-specific gene duplication and loss in human and great ape evolution
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human genes, across five hominoid species, including human. We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of the evolutionary age of each lineage, genes showing copy number expansions were most pronounced in human (134) and include a number of genes thought to be involved in the structure and function of the brain. This work represents, to our knowledge, the first genome-wide gene-based survey of gene duplication across hominoid species. The genes identified here likely represent a significant majority of the major gene copy number changes that have occurred over the past 15 million years of human and great ape evolution and are likely to underlie some of the key phenotypic characteristics that distinguish these species.
A species experiment design type assays differences between distinct species.
Keywords: species_design
Overall design Using regression correlation, arrayCGH, acCGH
Web link
Contributor(s) Kim Y
Citation(s) 15252450
Submission date Jan 05, 2006
Last update date Mar 16, 2012
Organization Stanford Microarray Database (SMD)
Phone 650-498-6012
Department Stanford University, School of Medicine
Street address 300 Pasteur Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
Platforms (2)
Samples (18)
GSM90753 GORILLA 1 [HSR (human female) vs. NG05251 (Gorilla male cell line)]
GSM90754 ORANG 1 [HSR (human female) vs. NG12256 (Orangutan female cell line)]
GSM90755 BONOBO 1 [HSJ (human male) vs. NG05253A (Bonobo cell line)]
BioProject PRJNA94243

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