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Series GSE40957 Query DataSets for GSE40957
Status Public on Jan 29, 2013
Title Brinker regulates wing disc growth in part via repression of Myc expression
Organism Drosophila melanogaster
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The molecular mechanisms regulating tissue size represent an unsolved puzzle in developmental biology. One signaling pathway controlling growth of the Drosophila wing is Dpp. Dpp promotes growth via repression of the transcription factor Brinker. The transcriptional targets of Brinker that control cell growth and proliferation, however, are not yet fully elucidated. We report here a genome-wide ChIP-seq of endogenous Brinker from wing imaginal discs. We identify the growth regulator Myc as a target of Brinker and show that Myc together with the microRNA bantam explain a large fraction of the growth inhibition caused by Brinker. This work sheds light on the effector mechanisms by which Dpp signaling controls tissue growth.
 
Overall design Identification of Brinker binding sites in Wing imaginal discs cells
 
Contributor(s) Doumpas N, Ruiz-Romero M, Blanco E, Edgar B, Corominas M, Teleman A
Citation(s) 23337628
Submission date Sep 18, 2012
Last update date May 15, 2019
Contact name Enrique Blanco
E-mail(s) enrique.blanco@crg.eu
Phone +34 93 316 01 00
Organization name Center for Genomic Regulation (CRG)
Department Gene Regulation, Stem Cells and Cancer
Lab Epigenetic Events in Cancer (L. Di Croce's lab)
Street address Dr. Aiguader 88
City Barcelona
ZIP/Postal code 08003
Country Spain
 
Platforms (1)
GPL9058 Illumina Genome Analyzer (Drosophila melanogaster)
Samples (1)
GSM1005585 Brinker ChIPSeq
Relations
BioProject PRJNA175435
SRA SRP015791

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Supplementary file Size Download File type/resource
GSE40957_RAW.tar 188.7 Mb (http)(custom) TAR (of BED, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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