GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE41188 Query DataSets for GSE41188
Status Public on Jan 12, 2013
Title High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development (aCGH)
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Prostate cancer research is hampered by a lack of preclinical models which accurately reproduce clinical heterogeneity. We have established a bank of transplantable patient-derived prostate tumor xenograft lines, using subrenal capsule grafting of human tumor tissue into immuno-deficient mice. This panel includes the first lines generated from prostate cancer biopsy tissue, and also new lines from metastatic tissue. The lines retained salient features of the original patient tumors, including histopathological and molecular characteristics. Furthermore, they span major subtypes of prostate cancer, capturing diverse inter- and intra-tumoral heterogeneity. Host castration led to the development of castrate-resistant tumors, including the first model of neuroendocrine transdifferentiation. This publicly-available resource provides novel tools for the next-generation of prostate cancer research and therapy development.
Overall design 3 primary tumors and 21 xenograft tumors
Contributor(s) Lin D, Wyatt AW, Brahmbhatt S, Haegert A, Anderson SA
Citation(s) 25544761, 25859291, 24589457
Submission date Sep 27, 2012
Last update date Oct 22, 2019
Contact name Shawn Anderson
Organization name Vancouver Prostate Centre
Lab Laboratory for Advanced Genome Analysis
Street address 2660 Oak Street
City Vancouver
State/province BC
ZIP/Postal code V6H3Z6
Country Canada
Platforms (2)
GPL10123 Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)
GPL10152 Agilent-021924 SurePrint G3 Human CGH Microarray 8x60K (Feature Number version)
Samples (24)
GSM1010225 Patient Derived Xenograft LTL-310
GSM1010226 Patient Derived Xenograft LTL-313A
GSM1010227 Patient Derived Xenograft LTL-313C
This SubSeries is part of SuperSeries:
GSE41193 High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development
BioProject PRJNA176140

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41188_RAW.tar 231.4 Mb (http)(custom) TAR (of TXT)
GSE41188_cohorts_Figure_11212012.pdf.gz 88.9 Kb (ftp)(http) PDF
Processed data included within Sample table
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap