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Series GSE41395 Query DataSets for GSE41395
Status Public on Nov 10, 2012
Title IP of 5-methylcytosine (5-hmC) enriched DNA fragments from control and PB treated mouse livers (1 day)
Organism Mus musculus
Experiment type Methylation profiling by genome tiling array
Summary 5-hmC is an epigenetic modification of the DNA base cytosine with roles in gene silencing events, imprinting and X inactivation. Phenobarbital (PB) is a well studied non-genotoxic carcinogen with roles in epigenetic perturbation. We profile 5hmC in both control mouse livers as well as in the livers of 1 day PB treated mice. 5hmC is largely found to reside in the bodies of active genes and promoter levels are perturbed upon PB induced gene activation events.
5-hmC is assocated with promoters fo silent genes. Upon PB exposire a handfull of genes are induced which reveal decreases in promoter 5hmC levels
 
Overall design comparison of 5-hmC profiles in 5 control and 5 PB exposed mouse livers (dose: 1day PB)
 
Contributor(s) LempiƤinen H, Thomson JP
Citation(s) 25985418
Submission date Oct 05, 2012
Last update date Jun 10, 2019
Contact name John Paterson Thomson
E-mail(s) john.thomson@igmm.ed.ac.uk
Organization name University of Edinburgh
Department MRC Human Genetics Unit
Lab Meehan
Street address Crewe Road
City Edinburgh
ZIP/Postal code EH4 2XU
Country United Kingdom
 
Platforms (1)
GPL16143 NimbleGen Mouse 2.1M deluxe promoter array (ver. 2)
Samples (10)
GSM1016379 control mouse 1 liver 5hmC profile (1d)
GSM1016380 control mouse 2 liver 5hmC profile (1d)
GSM1016381 control mouse 3 liver 5hmC profile (1d)
This SubSeries is part of SuperSeries:
GSE40540 IP of 5-hydroxymethylcytosine (5-hmC) and 5-methylcytosine (5-mC) enriched DNA fragments from control and PB treated mouse livers
Relations
BioProject PRJNA179299

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41395_RAW.tar 942.6 Mb (http)(custom) TAR (of PAIR)
GSE41395_hmedip_liver_1day_PB.txt.gz 227.2 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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