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Series GSE41398 Query DataSets for GSE41398
Status Public on Nov 10, 2012
Title IP of 5-methylcytosine (5-mC) enriched DNA fragments from control and PB treated mouse livers (91 day)
Organism Mus musculus
Experiment type Methylation profiling by genome tiling array
Summary 5-mC is an epigenetic modification of the DNA base cytosine with roles in gene silencing events, imprinting and X inactivation. Phenobarbital (PB) is a well studied non-genotoxic carcinogen with roles in epigenetic perturbation. We profile 5mC in both control mouse livers as well as in the livers of 91 day PB treated mice. 5mC is largely found to reside in the bodies of active genes and promoter levels are perturbed upon PB induced gene activation events.
5-mC is assocated with promoters fo silent genes. Upon PB exposire a handfull of genes are induced which reveal decreases in promoter 5mC levels
Overall design comparison of 5-mC profiles in 5 control and 5 PB exposed mouse livers (dose: 91day PB)
Contributor(s) LempiƤinen H, Thomson JP
Citation(s) 25985418
Submission date Oct 05, 2012
Last update date Jun 10, 2019
Contact name John Paterson Thomson
Organization name University of Edinburgh
Department MRC Human Genetics Unit
Lab Meehan
Street address Crewe Road
City Edinburgh
ZIP/Postal code EH4 2XU
Country United Kingdom
Platforms (1)
GPL16144 NimbleGen Mouse 2.1M deluxe promoter array (ver. 3)
Samples (10)
GSM1016409 control mouse 1 liver 5mC profile (91d)
GSM1016410 control mouse 2 liver 5mC profile (91d)
GSM1016411 control mouse 3 liver 5mC profile (91d)
This SubSeries is part of SuperSeries:
GSE40540 IP of 5-hydroxymethylcytosine (5-hmC) and 5-methylcytosine (5-mC) enriched DNA fragments from control and PB treated mouse livers
BioProject PRJNA179302

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41398_RAW.tar 904.6 Mb (http)(custom) TAR (of PAIR)
GSE41398_medip_liver_91day_PB.txt.gz 217.1 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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