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Status |
Public on Jun 30, 2013 |
Title |
Frequent truncating mutations of STAG2 in bladder cancer |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by genome tiling array Genome variation profiling by SNP array SNP genotyping by SNP array
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Summary |
Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
Affymetrix CytoScan HD Arrays were performed according to the manufacturer's directions on genomic DNA extracted directly from 12 snap-frozen human urothelial carcinoma primary tumors with somatic mutations of the STAG2 gene.
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Overall design |
Copy number analysis using Affymetrix CytoScan HD Arrays was performed for 12 human urothelial carcinomas of the bladder with truncating mutations of the STAG2 gene.
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Contributor(s) |
Solomon DA, Waldman T, Elkahloun A |
Citation(s) |
24121789 |
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Submission date |
Oct 15, 2012 |
Last update date |
Jul 13, 2018 |
Contact name |
David A. Solomon |
E-mail(s) |
david.solomon@ucsfmedctr.org
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Organization name |
University of California, San Francisco
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Department |
Pathology
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Street address |
513 Parnassus Ave, HSW 450
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City |
San Francisco |
State/province |
CA |
ZIP/Postal code |
94143 |
Country |
USA |
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Platforms (1) |
GPL16131 |
[CytoScanHD_Array] Affymetrix CytoScan HD Array |
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Samples (12)
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Relations |
BioProject |
PRJNA177576 |