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Series GSE41875 Query DataSets for GSE41875
Status Public on Mar 08, 2013
Title Genome variation profiling of Glioma Stem Cell lines
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary Glioblastoma multiforme (GBM), the most common and malignant type of glioma, is characterized by a poor prognosis and the lack of an effective treatment, which are due to a small sub-population of cells with stem-like properties, termed glioma stem cells (GSCs). The term “multiforme” describes the histological feature of this tumor, i.e. the cellular and morphological heterogeneity. At the molecular level multiple layers of alterations may reflect this heterogeneity providing together the driving force of tumor initiation and development. In order to decipher the common “signature” of the ancestral GSC population, we examined 5 already characterized GSC lines evaluating their copy number alterations using a genome-wide approach.
 
Overall design Genomic DNA was isolated from 5 Glioma Stem Cell (GSC) lines. Each sample was labeled with Cy3 dye and then hybridized against the same commercial reference DNA labeled in Cy5.
 
Contributor(s) Baronchelli S, Bentivegna A, Redaelli S, Riva G, Butta V, Paoletta L, Dalprà L
Citation(s) 23468990
Submission date Oct 26, 2012
Last update date Jun 20, 2013
Contact name Simona Baronchelli
Organization name University of Milan-Bicocca
Street address Via Cadore 48
City Monza
ZIP/Postal code 20900
Country Italy
 
Platforms (1)
GPL8841 Agilent-014950 Human Genome CGH Microarray 4x44K (Probe Name version)
Samples (5)
GSM1026856 GBM2_GSC line_1
GSM1026857 GBM7_GSC line_2
GSM1026858 G166_GSC line_3
Relations
BioProject PRJNA178370

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE41875_RAW.tar 23.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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