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Series GSE43265 Query DataSets for GSE43265
Status Public on Dec 31, 2017
Title An epigenetic panel of NEFH and HS3ST2 relates to overall survival in human ovarian cancer .
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary We used methylation DNA arrays to observe the genomic wild methylation profiles in 31 malignant ovarian tumors. After validations, we selected, NEFH and HS3ST2. We used bisulfite pyrosequencing to expose methylation status for 84 independent samples. Kaplan–Meier survival and Cox regression analysis estimates the association with ovarian cancer outcome. We discovered patients with high methyatlion of two genes, had a shorter median 5-years overall survival. We also evaluated the high-methylation of a panel genes in patients, that presented as an independat factor for associated with poor outcomes. High-methylation of NEFH and HS3ST2 are provided the prognostic index for the poor outcome of overall survival in ovarian cancers.
Overall design Bisulphite converted DNA from the 31 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2
Contributor(s) Huang R, Lai H
Citation(s) 29732534
Submission date Jan 03, 2013
Last update date Jul 30, 2018
Contact name Hung-Cheng Lai
Organization name Taipei Medical University
Department Department of Obstetrics and Gynecology, School of Medicine, College of Medicine,
Street address No.250, Wuxing St.
City Taipei
ZIP/Postal code 11031
Country Taiwan
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (31)
GSM1059655 Ovarian_PrimarySurgery_L513
GSM1059656 Ovarian_PrimarySurgery_L991
GSM1059657 Ovarian_PrimarySurgery_LA73
BioProject PRJNA185174

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43265_RAW.tar 5.8 Mb (http)(custom) TAR
GSE43265_non_normalized.txt.gz 6.1 Mb (ftp)(http) TXT
Processed data included within Sample table

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