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Status |
Public on Jun 05, 2013 |
Title |
Thymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array Methylation profiling by genome tiling array
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Summary |
A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy.
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Overall design |
Each sample was fluorescently labeled and hybridized to Roche Nimblegen 2.1M Deluxe Promoter Arrays and Expression arrays.
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Contributor(s) |
Koczor CA, Lewis W |
Citation(s) |
23695888, 23695887 |
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Submission date |
Jan 10, 2013 |
Last update date |
Jun 05, 2013 |
Contact name |
William Lewis |
Organization name |
Emory University
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Department |
Pathology
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Lab |
Lewis Lab
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Street address |
101 Woodruff Circle
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City |
Atlanta |
State/province |
Georgia |
ZIP/Postal code |
30322 |
Country |
USA |
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Platforms (2) |
GPL15338 |
Nimblegen Homo sapiens HG18 Expression Array (12x135k) [gene-level] |
GPL16284 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
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Samples (40)
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Relations |
BioProject |
PRJNA186556 |