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Series GSE43746 Query DataSets for GSE43746
Status Public on Jul 10, 2013
Title Dysregulation of the colonic mucosally-adherent microbiota associates with HIV disease progression.
Platform organisms Bacteria; Archaea
Sample organism Homo sapiens
Experiment type Expression profiling by array
Summary HIV is known to severely affect the gastrointestinal immune system, in particular compartments of immunity that regulate gut microbial composition. Furthermore, recent studies in mice have shown that dysregulation of the gut microbiome can contribute to chronic inflammation, which is a hallmark of HIV and is thought to fuel disease progression. We sought to understand whether the gut microbial community differs in HIV-infected subjects, and whether such putative differences are associated with disease progression.
We found that dysbiosis in the gut mucosally-adherent bacterial community associates with markers of chronic inflammation and disease progression in HIV-infected subjects, and this dysbiosis remains in many subjects undergiong antiretroviral therapy.
 
Overall design We used G3 PhyloChip microarrays (commercially available from Second Genome, Inc.) to profile gut bacteria in rectosigmoid biopsies from 32 subjects: 6 HIV-infected viremic untreated (VU), 18 HIV-infected subjects on highly active antiretroviral therapy (HAART), 1 HIV-infected long-term non-progressor that is untreated (LTNP), and 9 HIV-uninfected subjects (HIV-).
 
Contributor(s) Vujkovic-Cvijin I, McCune JM, Lynch SV
Citation(s) 23843452
Submission date Jan 24, 2013
Last update date Aug 05, 2013
Contact name Ivan Vujkovic-Cvijin
E-mail(s) ivan.vujkovic-cvijin@ucsf.edu
Organization name University of California, San Francisco
Street address 1001 Potrero Ave, Bldg 3
City San Francisco
State/province California
ZIP/Postal code 94117
Country USA
 
Platforms (1)
GPL16546 [PhyloChip] Affymetrix G3 PhyloChip
Samples (34)
GSM1070197 rectosigmoid biopsy_Patient ID: 3010
GSM1070198 rectosigmoid biopsy_Patient ID: 4001
GSM1070199 rectosigmoid biopsy_Patient ID: 1415
Relations
BioProject PRJNA187524

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Supplementary file Size Download File type/resource
GSE43746_RAW.tar 194.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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