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| Status |
Public on Sep 01, 2013 |
| Title |
Methylated DNA immunoprecipitation coupled with NimbleGen's array to identify methylated genes in pancreatic ductal adenocarcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive cancer with a poor prognosis. Using methylated DNA immunoprecipitation (MeDIP)-chip analysis, we found that 161 genes that were specifically hypermethylated in PANC-1 cells. Among them, miR-615-5p was hypermethylated in its putative promoter region, which silenced its expression in PDAC cell lines.
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| Overall design |
Comparison between PANC-1 cell lines and normal pancreas tissue
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| Contributor(s) |
Gao W, Miao Y |
| Citation missing |
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| |
| Submission date |
Feb 28, 2013 |
| Last update date |
Sep 03, 2013 |
| Contact name |
wentao gao |
| E-mail(s) |
gao11@hotmail.com
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| Phone |
13584026196
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| Fax |
86-25-83781992
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| Organization name |
the first affiliated hospital with nanjing medical university
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| Department |
Department of General Surgery
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| Street address |
300 Guangzhou Road
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| City |
Nanjing |
| ZIP/Postal code |
210029 |
| Country |
China |
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| Platforms (1) |
| GPL16062 |
NimbleGen Human DNA Methylation 385K Promoter Plus CpG Island Array [2006-11-02_HG18_CpG_Promo] |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA191147 |
