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Series GSE46280 Query DataSets for GSE46280
Status Public on Apr 24, 2013
Title Expression data of multiple sclerosis patients receiving Interferon-beta therapy [HG-U133_Plus_2]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS).
By using Affymetrix microarrays, we obtained gene expression profiles of peripheral blood mononuclear cells from 6 patients within the first month of IFN-beta treatment.
Overall design EDTA blood samples were taken from all patients immediately before first, second and third IFN-beta injection as well as after 1 month.
Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labeled and hybridized to Affymetrix Human Genome U133 Plus 2.0 arrays to quantify the mRNA levels.
This GEO entry provides the U133 Plus 2.0 microarray data.
Contributor(s) Hecker M, Koczan D, Zettl UK
Citation(s) 23921681
Submission date Apr 22, 2013
Last update date Aug 08, 2013
Contact name Michael Hecker
Organization name University of Rostock
Department Department of Neurology
Lab Division of Neuroimmunology
Street address Gehlsheimer Str. 20
City Rostock
ZIP/Postal code 18147
Country Germany
Platforms (1)
GPL15445 Affymetrix Human Genome U133 Plus 2.0 Array [CDF:gahgu133plus2_2.2.0]
Samples (24)
GSM1128081 Patient 1, before first IFN-beta injection
GSM1128082 Patient 1, before second IFN-beta injection
GSM1128083 Patient 1, before third IFN-beta injection
This SubSeries is part of SuperSeries:
GSE46293 Expression data of multiple sclerosis patients receiving Interferon-beta therapy
BioProject PRJNA198641

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46280_RAW.tar 121.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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