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Series GSE46317 Query DataSets for GSE46317
Status Public on Apr 24, 2013
Title Drosophila CNS glial microarray
Organism Drosophila melanogaster
Experiment type Expression profiling by array
Summary Gliogenesis in the Drosophila CNS occurs during embryogenesis and also during the postembryonic larval stages. Several glial subtypes are generated in the postembryonic CNS through the proliferation of differentiated glial cells. The genes and molecular pathways that regulate glial proliferation in the postembryonic CNS are poorly understood. In this study we aimed to use gene expressing profiling of CNS tissue enriched in glia to identify genes expressed in glial cells in the postembryonic CNS.
We used microarrays to compare the gene expression profiles from the larval CNS of animals that had increased numbers of glial cells to identify genes that are expressed in glia.
Overall design RNA was purified from the late third instar larval CNS from control larvae, or larvae expressing an activated form of the FGF receptor (Hlt[ACT]), or overexpressing the insulin receptor (InR) in glial cells using the glial specific driver repoGal4 to increase the number of glial cells and generate CNS tissue enriched in glia.
Contributor(s) Bateman JM, Avet-Rochex A
Citation(s) 25217886
Submission date Apr 23, 2013
Last update date May 04, 2018
Contact name Joseph M. Bateman
Phone 2078488144
Organization name King's College London
Street address Guy's campus
City London
State/province (Click to Select US State)
ZIP/Postal code SE1 1UL
Country United Kingdom
Platforms (1)
GPL1322 [Drosophila_2] Affymetrix Drosophila Genome 2.0 Array
Samples (9)
GSM1128592 CNS_control_rep1
GSM1128593 CNS_control_rep2
GSM1128594 CNS_control_rep3
BioProject PRJNA198727

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Supplementary file Size Download File type/resource
GSE46317_RAW.tar 17.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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