|
| Status |
Public on Apr 27, 2013 |
| Title |
The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: Role of endogenous toll-like receptor (TLR) ligands |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Genome wide expression study of the effect of single stranded RNA (ssRNA) in A/JOlaHsd (WT), A/J and A/J-MyD88 deficient mice. The hypothesis for this study was that endogenous TLR ligands released from the leaking dysferlin-deficient muscle fibers engage TLRs on muscle and immune cells and contribute to disease progression.These data point to a clear role for the TLR pathway in the pathogenesis of dysferlin deficiency.
|
| |
|
| Overall design |
Total RNA obtained from isolated tibalis anterior muscles (TA) of A/JOlaHsd (WT), A/J and A/J-MyD88 deficient mice that were subjected to 3 intramuscular injections of ssRNA over the period of 10 days compared to their contraleteral legs that were injected with saline (control).
|
| |
|
| Citation(s) |
23857504 |
| |
| Submission date |
Apr 26, 2013 |
| Last update date |
Jan 16, 2019 |
| Contact name |
kitipong Uaesoontrachoon |
| E-mail(s) |
kuaesoon@cnmc.org
|
| Organization name |
Children's national medical center
|
| Street address |
111 Michigan Ave, NW
|
| City |
DC |
| State/province |
Washington |
| ZIP/Postal code |
20010 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA200304 |
Less...
More...