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Series GSE46420 Query DataSets for GSE46420
Status Public on Apr 27, 2013
Title The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: Role of endogenous toll-like receptor (TLR) ligands
Organism Mus musculus
Experiment type Expression profiling by array
Summary Genome wide expression study of the effect of single stranded RNA (ssRNA) in A/JOlaHsd (WT), A/J and A/J-MyD88 deficient mice. The hypothesis for this study was that endogenous TLR ligands released from the leaking dysferlin-deficient muscle fibers engage TLRs on muscle and immune cells and contribute to disease progression.These data point to a clear role for the TLR pathway in the pathogenesis of dysferlin deficiency.
Overall design Total RNA obtained from isolated tibalis anterior muscles (TA) of A/JOlaHsd (WT), A/J and A/J-MyD88 deficient mice that were subjected to 3 intramuscular injections of ssRNA over the period of 10 days compared to their contraleteral legs that were injected with saline (control).
Citation(s) 23857504
Submission date Apr 26, 2013
Last update date Jan 16, 2019
Contact name kitipong Uaesoontrachoon
Organization name Children's national medical center
Street address 111 Michigan Ave, NW
City DC
State/province Washington
ZIP/Postal code 20010
Country USA
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (18)
GSM1129950 A/JOlaHsd_saline 1
GSM1129951 A/JOlaHsd_saline 2
GSM1129952 A/JOlaHsd_saline 3
BioProject PRJNA200304

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46420_RAW.tar 15.8 Mb (http)(custom) TAR
GSE46420_non-normalized.txt.gz 5.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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