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Series GSE46436 Query DataSets for GSE46436
Status Public on Apr 27, 2013
Title Expression data from neonatal rat ovaries following LPS exposure
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Inflammatory processes play an important role in regulation of ovarian development, in particularly early in life. Neonatal immune challenge by administration of lipopolysaccharide (LPS) has been previously demonstrated to result in diminished ovarian reserve and altered reproductive lifespan. In this study we aimed to characterise the cellular mechanisms that may underpin impaired ovulatory capacity and reduced oocyte development, induced by LPS treatment. Rat pups were administered with LPS or saline on postnatal days 3 and 5. Ovaries were obtained on postnatal day 7 to examine the effect of LPS administration on the ovarian transcriptome.
Overall design Rat pups were administered intraperitoneally either 0.05mg/kg of LPS (Salmonella Enteritidis) or an equivalent volume of non-pyrogenic saline on postnatal days (PNDs) 3 and 5, and ovaries were obtained on PND 7 for RNA extraction and hybridization on an Agilent-028279 SurePrint G3 Rat GE 8x60K Array platform.
Contributor(s) Sominsky L, Sobinoff AP, McLaughlin EA, Hodgson DM
Citation(s) 23781169
Submission date Apr 26, 2013
Last update date Jul 27, 2013
Contact name Luba Sominsky
Organization name The University of Newcastle
Lab Laboratory of Neuroimmunology
Street address University Drive
City Callaghan
State/province NSW
ZIP/Postal code 2308
Country Australia
Platforms (1)
GPL14797 Agilent-028279 SurePrint G3 Rat GE 8x60K Microarray (Feature Number version)
Samples (6)
GSM1130128 Saline control, rep 1
GSM1130129 Saline control, rep 2
GSM1130130 Saline control, rep 3
BioProject PRJNA200339

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46436_RAW.tar 43.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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