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Series GSE46558 Query DataSets for GSE46558
Status Public on May 02, 2013
Title Differentially expressed miRNA in burned murine skin tissue compared to normal skin tissue
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary Interactions between stromal cell-derived factor-1α (SDF-1α) and its cognate receptor CXCR4 are crucial for the recruitment of mesenchymal stem cells (MSCs) from bone marrow (BM) reservoirs to damaged tissues for repair during alarm situations. MicroRNAs are differentially expressed in stem cell niches, suggesting a specialized role in stem cell regulation. Here, we gain insight into the molecular mechanisms involved in regulating SDF-1α.
Individualized outcome prediction classifiers were successfully constructed through expression profiling of microRNAs (in all organisms as annotated in Sanger miRBase Release 11.0 (http://microrna.sanger.ac.uk))in one burned murine skin tissue compared to normal skin tissue,which had 57 upregulated microRNAs and 28 down-regulated microRNAs.
 
Overall design In the study presented here, a consecutively operated, well-defined cohort of 2 cases, was used to acquire expression profiles of microRNAs (in all organisms as annotated in Sanger miRBase Release 11.0 (http://microrna.sanger.ac.uk)), leading to the successful construction of supervised. The most recent version of the array (v.11.0 - hsa, mmu & rno array) contains more than 1700 capture probes, covering all microRNAs annotated in miRBase 11.0, as well as all viral microRNAs, related to these species.
 
Contributor(s) Chen LH
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Submission date May 01, 2013
Last update date May 10, 2016
Contact name li mu han
E-mail(s) limcq@163.com
Organization name Southwest Hospital, Third Military Medical University
Street address gaotanyuan street
City chongqing
ZIP/Postal code 400038
Country China
 
Platforms (1)
GPL17107 Exiqon miRCURY LNA™ microRNA Array - hsa, mmu & rno
Samples (2)
GSM1132398 alive, burned skin tissue B1
GSM1132399 alive, normal skin tissue N1
Relations
BioProject PRJNA200962

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46558_Normalized_Data.txt.gz 19.2 Kb (ftp)(http) TXT
GSE46558_RAW.tar 1.0 Mb (http)(custom) TAR (of GPR)
Processed data are available on Series record

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