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Series GSE46568 Query DataSets for GSE46568
Status Public on Sep 11, 2013
Title Expression data from mouse liver tissue from SKH:QS mice treated with 68ZnO sunscreens
Organism Mus musculus
Experiment type Expression profiling by array
Summary ZnO nanoparticles can elicit a range of perturbed cell responses in vitro. Exposure to topically applied sunscreens containing ZnO particles may or may not elicit a biological effect in mice.
We aimed to determine whether exposure to topically applied ZnO particles manufactured as either microparticles or nanoparticles could elicit a biological response in liver tissue isolated from treated mice, compared to the sunscreen formulation only or untreated mice.
 
Overall design Sunscreens containing 68ZnO microparticles, 68ZnO nanoparticles or no metal oxide particles at all (formulation only) were applied to the backs of SKH:QS mice six times over four days. On the fifth day mice were sacrificed and liver tissue was harvested for RNA isolation and whole genome transcriptional profiling, comparing the expression profiles of treated mice with untreated mice. Two separate experiments were conducted, one using virgin mice and the other using pregnant mice (~17d gestation)
 
Contributor(s) Osmond M, Oytam Y
Citation(s) 24266363
Submission date May 02, 2013
Last update date Mar 04, 2019
Contact name Megan Osmond-McLeod
E-mail(s) megan.osmond@csiro.au
Organization name CSIRO
Street address 11 Julius Avenue
City North Ryde
ZIP/Postal code 1670
Country Australia
 
Platforms (1)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Samples (46)
GSM1132543 Virgin mouse_liver tissue_formulation-only_5d, biological rep 1
GSM1132544 Virgin mouse_liver tissue_formulation-only_5d, biological rep 2
GSM1132545 Virgin mouse_liver tissue_formulation-only_5d, biological rep 3
Relations
BioProject PRJNA201400

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE46568_RAW.tar 167.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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