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Series GSE48679 Query DataSets for GSE48679
Status Public on Mar 05, 2016
Title Genome-wide maps of Meis1, Hoxa9 and Pbx binding sites in murine myeloid leukemia cells
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We have searched genome-wide binding sites of homeodomain proteins important for leukemogenesis in Hoxa9- and Meis1- induced myeloid leukemia cells. Thousands of binding sites of these three family proteins have been identified and many of them are co-localized with those of each others. Hoxa9 and Pbx binding sites were compared between the presence and absence of Meis1 by its knockout in the same cells. In combination of the results with gene expression profiles of the same cells, important downstream target genes of Meis1 in leukemogenesis have been identified.
 
Overall design Examination of binding sites of 3 transcription factors in a single cell with 2 different conditions
 
Contributor(s) Yokoyama T, Nakamura T
Citation(s) 27018596
Submission date Jul 10, 2013
Last update date May 15, 2019
Contact name Takuro Nakamura
E-mail(s) takuro-ind@umin.net
Phone 81-3-3570-0462
Organization name Japanese Foundation for Cancer Research
Department The Cancer Institute
Lab Carcinogenesis
Street address 3-8-31 Ariake, Koto-ku
City Tokyo
ZIP/Postal code 135-8550
Country Japan
 
Platforms (1)
GPL9185 Illumina Genome Analyzer (Mus musculus)
Samples (6)
GSM1183374 Meis1_ChIPSeq
GSM1183375 Hoxa9_ChIPSeq
GSM1183376 Hoxa9 wo Meis1_ChIPSeq
Relations
BioProject PRJNA211181
SRA SRP026692

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE48679_RAW.tar 28.2 Mb (http)(custom) TAR (of BAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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