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| Status |
Public on Aug 01, 2015 |
| Title |
The effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we investigated the effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model as vitamin D is known to have a spectrum of anticancer activities. Using PET, we found that tumor formation and progression were suppressed in rats fed a diet supplemented with 6 IU/g vitamin D3(+6D) as compared to the group fed a 2 IU/g vitamin D3 diet (+2D) or controls. Microarray analysis of the tumors that arose revealed that vitamin D supplementation caused significant up- and down regulation in 21 and 16 genes, respectively.
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| Overall design |
There are 9 tissue samples (3 rats in each group labeled as (+6), (+2) and control). Duplicate analysis were used for each sample.
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| Contributor(s) |
Chiang K, Yeh C, Lin K, Su L, Yen T, Pang JS, Kittaka A, Sun C, Chen M, Jan Y, Juang H, Yeh T, Chen TC |
| Citation(s) |
24939880 |
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| Submission date |
Jul 17, 2013 |
| Last update date |
Nov 05, 2015 |
| Contact name |
Chun-Nan Yeh |
| E-mail(s) |
yehchunnan@gmail.com
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| Organization name |
Chang Gung Medical Foundation
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| Department |
General Surgery
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| Street address |
No.5, Fusing St.
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| City |
Gueishan Township |
| State/province |
Taoyuan County |
| ZIP/Postal code |
333 |
| Country |
Taiwan |
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| Platforms (1) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA212404 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE48961_RAW.tar |
45.3 Mb |
(http)(custom) |
TAR (of GPR) |
| GSE48961_avrg_data.txt.gz |
4.2 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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