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Series GSE50637 Query DataSets for GSE50637
Status Public on Sep 06, 2013
Title Transcriptional regulation patterns revealed by high-resolution chromatin immunoprecipitation during cardiac hypertrophy
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Purpose: To identify the differential transcriptional patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts
Results: Our data revealed novel transcriptional patterns during cardiac growth conditions. The results showed that most of the essential genes are regulated by promoter clearance of paused RNA pol II, while de novo recruitment is required for regulation of mostly speclaized genes during cardiac growth. We have identified two major modes of gene regulation durign cardiac hypertrophy and four transcriptional growth patterns. The results are published in January 2013 issue of Journal of Biological Chemistry.
Overall design Methods: Hearts were extracted from 1-2day old C57 mice, from mice subjecetd to Transaortic coarctation or adult mice. The hearts were sent to Active Motif for RNA polII and H3K9ac- ChIP-Seq.
Contributor(s) Abdellatif M, Sayed D
Citation(s) 23229551, 25398966, 29524612, 26675618
Submission date Sep 05, 2013
Last update date Oct 09, 2019
Contact name Danish Sayed
Phone (973) 972-5243
Organization name Rutgers-NJMS
Department CBMM
Lab MSB G 626
Street address 185 south orange avenue
City Newark
State/province NJ
ZIP/Postal code 07103
Country USA
Platforms (1)
GPL9250 Illumina Genome Analyzer II (Mus musculus)
Samples (7)
GSM1225096 polII_ChIP-seq adult
GSM1225097 pol II_ChIP-seq TAC-hypertrophied
GSM1225098 polII_ChIP-seq neonate
BioProject PRJNA218141
SRA SRP029607

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE50637_RAW.tar 700.8 Mb (http)(custom) TAR (of BAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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