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| Status |
Public on Nov 08, 2013 |
| Title |
Chip-chip from Hepatocellular carcinoma (HCC) specimens with H3K4me3 |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
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| Summary |
Epigenetic changes commonly occur in hepatocellular carcinoma (HCC) and are associated with aberrant gene expression. Recently, we demonstrated the pivotal role of abnormal H3K4me3 methylation, which is catalyzed by the menin/MLL, a TrxG family, in HCC development. Meanwhile, there is clear evidence that increasing global levels of H3K27me3 are activated in human primary HCC.
To further elucidate the functional relatedness of the active H3K4me3 and repressive H3K27me3 histone remodeling in HCC, we performed H3K4me3 and H3K27me3 ChIP-on-chip screen using three HCC specimens and their adjacent tissues.
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| Overall design |
Comparison of ChIP-on-chip results between tumor(C) and adjacent tissues(N) from three HCC specimens with H3K4me3
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| Contributor(s) |
Xu B, Gao S |
| Citation missing |
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| |
| Submission date |
Nov 07, 2013 |
| Last update date |
Nov 10, 2013 |
| Contact name |
Shubin Gao |
| E-mail(s) |
shbgao@xmu.edu.cn
|
| Phone |
+86-592-218-1535
|
| Organization name |
Medical College,Xiamen University
|
| Department |
Basic Medical Sciences
|
| Street address |
Chengzhi building 110,Xiang'an South Road
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| City |
Xiamen |
| ZIP/Postal code |
361102 |
| Country |
China |
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| Platforms (1) |
| GPL9448 |
NimbleGen Human HG18 RefSeq Promoter 385K tiling array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA227135 |
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